PMID: 6160404Dec 11, 1980Paper

Interferon suppresses antigen- and mitogen-induced leukocyte migration inhibition

Nature
R SzigetiG Klein

Abstract

Although first recognized by its effect on virus-cell interactions, interferon (IFN) has a variety of other effects. It can affect cell proliferation, modify the immune response at several levels, enhance the cytotoxic action of lymphocytes, suppress antibody formation and inhibit the development of delayed-type hypersensitivity (DTH) reactions. Therefore we have now tested the effect of interferon on leukocyte migration inhibition (LMI), regarded as the counterpart in vitro of DTH in humans. We have found that IFN suppresses both mitogen-and antigen-induced LMI, acting directly on the granulocytes but also affecting the lymphokine production of the lymphocytes.

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Citations

Jan 1, 1986·Archives of Dermatological Research·A KappE Schöpf
Jan 1, 1982·Journal of Interferon Research·C M JonesS Pestka
Jan 1, 1983·Journal of Interferon Research·A ParafE De Maeyer
Oct 1, 1986·Journal of Interferon Research·I RosztóczyI Béládi
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qiao TongAsma Nusrat

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