Interferon-tau and pregnancy.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
R M Roberts

Abstract

A type I interferon known as IFN-tau is expressed massively by the outer epithelium (trophectoderm) of the preimplantation trophoblast of ruminant ungulate species, such as cattle and sheep, for a few days during early pregnancy. They signal to the mother that she is pregnant and indirectly prevent regression of the corpus luteum so that progesterone production is maintained and normal ovarian cyclicity avoided. Despite their clear roles as reproductive hormones, the IFN-tau have the typical antiviral, antiproliferative, and immunomodulatory activities of other type I IFN. They are most closely related to the 172 amino acid IFN-omega. Unlike other type I IFN, they are not virally inducible and appear to be produced constitutively as the trophectoderm first forms during the development of the blastocyst. The discovery of the IFN-tau illustrates the diverse activities of interferons and their likely involvement in the normal embryonic development of mammals. The diversity of mechanisms different groups of mammals use to prolong the functional life span of the corpus luteum in early pregnancy is probably the consequence of genetic conflict between the genes of the mother and her offspring, which has led to remarkably high rates of...Continue Reading

References

Aug 1, 1989·Journal of Interferon Research·R M Roberts

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Citations

Jun 25, 2005·International Immunology·Christine Rogez-KreuzPascal Clayette
Aug 20, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Christine Rogez-KreuzPascal Clayette
Aug 24, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·O BouéM Rodríguez
Sep 27, 2018·Reproduction, Fertility, and Development·Iside ScaravaggiStefan Bauersachs
Jul 17, 2018·Biology of Reproduction·Koji Yoshinaga
Feb 1, 2020·Trends in Ecology & Evolution·Dakota E McCoy, David Haig
Dec 29, 1998·Biochimie·F LefèvreC La Bonnardière
Nov 25, 2004·Prostaglandins & Other Lipid Mediators·A GuzelogluW W Thatcher

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