Interferon-tau (IFNtau) regulation of IFN-stimulated gene expression in cell lines lacking specific IFN-signaling components.

Endocrinology
M D StewartT E Spencer

Abstract

Interferon-tau (IFNtau) is a unique type I IFN secreted by the ruminant conceptus that acts in a paracrine manner on the endometrial epithelium to signal pregnancy recognition. In the ovine endometrium, IFNtau suppresses estrogen receptor alpha and oxytocin receptor gene expression, but increases or induces expression of IFN-simulated genes (ISGs), including signal transducer and activator of transcription-1 (STAT1), STAT2, ISG factor-3gamma (ISGF3gamma)/p48/IFN regulatory factor-9, and 2',5'-oligoadenylate synthetase (OAS). Human fibroblast cell lines lacking specific IFN signaling components were employed to determine the roles of STAT1, STAT2, and ISGF3gamma in the effects of IFNtau on ISG protein expression. Results indicated that STAT1alpha or STAT1beta is required for IFNtau effects on STAT2, ISGF3gamma, and OAS (40/46, 69/71, and 100 kDa). STAT2 is required for effects on STAT1, ISGF3gamma, and all OAS forms. ISGF3gamma is required for effects of IFNtau on STAT2 and 40/46- and 69/71-kDa OAS and plays a role in the effects of IFNtau on 100-kDa OAS and STAT1. Mutation of Tyr(701), but not Ser(727), of STAT1 abolished the effects of IFNtau on ISG expression. Mutation of the SH2 domain of STAT1 abolished the effects of IFNta...Continue Reading

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Citations

May 2, 2008·Biology of Reproduction·Gwonhwa SongThomas E Spencer
Jan 24, 2002·Biology of Reproduction·M David StewartThomas E Spencer
Dec 19, 2002·Endocrinology·Karen D CarpenterThomas E Spencer
Jul 31, 2003·Reproduction in Domestic Animals = Zuchthygiene·E WolfF Sinowatz
May 31, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Toru TakahashiKazuyoshi Hashizume
Dec 17, 2014·Biology of Reproduction·Kelsey Brooks, Thomas E Spencer
Mar 12, 2002·The Journal of Biological Chemistry·Anna SpagnoliRon G Rosenfeld
Apr 11, 2021·Cell and Tissue Research·Daichi NishinoNobuhiko Yamauchi

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