Interferon therapy for COVID-19 and emerging infections: Prospects and concerns

Cleveland Clinic Journal of Medicine
Leonard H CalabreseCassandra Calabrese

Abstract

Numerous immunomodulating agents are currently being studied in clinical trials for the treatment of COVID-19, including interferon therapies. Interferons are naturally occurring host antiviral proteins upstream of the inflammatory pathway that are released by host cells in response to the presence of viral pathogens. It is known that beta coronaviruses deploy anti-interferon defenses to escape host innate immunity early in the infection course, and thus interferons have become attractive candidates for treatment of COVID-19. Questions surrounding timing, type of interferon, and route of administration all remain unanswered. Here we discuss the role of interferons in host antiviral immunity, and review the current data surrounding use of interferons in COVID-19.

Citations

Feb 28, 2021·Current Microbiology·Arezoo Beig ParikhaniKayhan Azadmanesh
Mar 23, 2021·The Journal of International Medical Research·Kanchana Sukumar, Anupama Tadepalli
Jul 4, 2021·Cellular Immunology·Seyed Mostafa MonzaviSamad Muhammadnejad
Jul 30, 2021·Journal of Inflammation Research·Decsa Medika HertantoCitrawati Dyah Kencono Wungu
Sep 18, 2021·Molecular Medicine·Douglas F NixonNathaniel Hupert

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