PMID: 7526789Jul 1, 1994Paper

Interferon therapy for the anti-HBe positive form of chronic hepatitis B

Antiviral Research
A Alberti, G Fattovich

Abstract

Two distinct serologic types of chronic hepatitis B have been identified, namely the "classical" HBeAg positive form and the "atypical" HBeAg negative, anti-HBe positive variant which is due to infection by a mutant HBV having a pre-core stop codon that makes the virus unable to produce HBeAg. The anti-HBe positive form is currently the prevalent type of chronic hepatitis B in the Mediterranean area, being associated with a more severe clinical course compared to HBeAg positive cases. The response to interferon therapy in patients with anti-HBe positive chronic hepatitis B has been recently investigated in control trials. These studies have shown that normalization of ALT with efficient suppression of virus activity can be achieved in 50-80% of patients while treated with interferon alpha indicating that also the pre-core mutant of HBV is sensitive to the antiviral effect of interferon. However, reactivation of hepatitis occurs in a variable percentage of initial responders when interferon is stopped. The probability of reactivation increases when the disease is of long duration, when cirrhosis is present and particularly if the pre-core mutant of HBV has become the predominant type of circulating virus, indicating that this HB...Continue Reading

References

Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G FattovichG Busatto
Aug 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M R BrunettoF Bonino
Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G FattovichG Realdi
Jul 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H HoofnagleH Popper
Nov 1, 1983·Digestive Diseases and Sciences·A AlbertiG Realdi
Dec 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M G SalehR Williams

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Citations

Nov 30, 2000·Journal of Hepatology·G Y MinukP Temple
Nov 13, 2001·Journal of Viral Hepatitis·P Merle, C Trepo
Sep 1, 1996·Drug and Alcohol Review·R G Batey, S J Bollipo
Dec 31, 1997·Journal of Clinical Gastroenterology·M KakoM Mayumi
Aug 26, 1998·Journal of Gastroenterology and Hepatology·R C GuptanS K Sarin
Jan 1, 1996·Scandinavian Journal of Infectious Diseases·K Kidd-Ljunggren
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David Milich, T Jake Liang

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