Interferons: biological and clinical effects.

Seminars in Surgical Oncology
B E Nelson, E C Borden

Abstract

Interferons play a key role in the immune system as biological response modifiers. Interferons alpha, beta, and gamma have been characterized, their nucleotide sequences defined, and the proteins produced by recombinant DNA technology. The myriad actions of interferons include enhancement of natural killer cell activity and antigen expression, induction of varied proteins, activation of macrophages, and antiviral, antiproliferative and antitumor effects. Clinical trials have demonstrated efficacy of interferons in some malignancies and ongoing studies are investigating results of combinations with other biological response modifiers and cytotoxic agents.

References

Apr 15, 1977·International Journal of Cancer. Journal International Du Cancer·H Strander, S Einhorn
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M RubinsteinS Pestka
Jun 1, 1979·Experimental Cell Research·L M PfefferI Tamm
Jan 1, 1979·Scandinavian Journal of Immunology·E SakselaK Cantell
Aug 24, 1978·Nature·F Balkwill, J Taylor-Papadimitriou
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C ChanyA Boué
Feb 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R QuesadaJ U Gutterman
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H YasuiO Hayaishi
Mar 1, 1987·Investigative Radiology·G J StantonS Baron
Mar 1, 1987·Reviews of Infectious Diseases·D A Tyrrell
Jan 1, 1986·Journal of Hepatology·A MorrisM Blackman
Aug 8, 1987·Lancet·F R Balkwill, J F Smyth
Oct 1, 1987·Journal of Interferon Research·J R Quesada, J U Gutterman
Oct 1, 1987·Journal of Interferon Research·E C BordenG I Byrne
Jan 1, 1987·Cancer Metastasis Reviews·M Shearer, J Taylor-Papadimitriou
Apr 6, 1988·Journal of the National Cancer Institute·E C Borden
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A RashidbaigiS Pestka
Jun 30, 1987·Biochemical and Biophysical Research Communications·J B KleinW L Dean
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M OhlssonA von Gabain
Oct 1, 1987·Atherosclerosis·I B RosenzweigE S Shrago
Nov 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M S ErnstoffJ M Kirkwood
Apr 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R D'AcquistoJ L Lewis
Aug 1, 1988·American Journal of Clinical Oncology·C E WelanderE A Levin
Mar 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F M TortiJ Hannigan
Feb 1, 1987·Cancer·P A VolberdingR J Spiegel
Feb 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H B MussM S Mitchell
Jul 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A C BuzaidS E Salmon

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Citations

Jan 1, 1992·Clinical Immunology and Immunopathology·E C Borden
May 8, 2000·The Journal of Urology·C P PavlovichM A O'Donnell
May 7, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hidetsugu AsadaOsam Mazda
Dec 1, 1992·Journal of Interferon Research·E C BordenD R Parkinson
May 1, 1997·Immunopharmacology and Immunotoxicology·Q LiC T Bever
Jul 1, 1996·The Pediatric Infectious Disease Journal·A S LauM C Yeung
Jan 1, 1995·Annals of Neurology·B Weinstock-GuttmanR A Rudick
Jul 1, 1991·Seminars in Surgical Oncology·J M McGee
Jun 19, 1992·International Journal of Cancer. Journal International Du Cancer·N SuzukiM Saito-Ebihara

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