PMID: 2497154Apr 1, 1989Paper

Interferons in dermatology

Journal of the American Academy of Dermatology
R StadlerC Orfanos

Abstract

Interferons are a large family of proteins and glycoproteins, naturally occurring or artificially produced by recombinant biotechnology. Their antiviral, antiproliferative, antitumoral, and immunomodulatory activities are induced by alterations in cell metabolism after binding to specific membrane receptors. Interferons have been used for the treatment of viral papillomas (e.g., verruca vulgaris and condyloma acuminatum), human immunodeficiency virus (HIV)-associated Kaposi's sarcoma and cutaneous tumors (e.g., melanoma, cutaneous T cell lymphoma, and basal cell carcinoma), and inflammatory dermatoses (e.g., Behçet's syndrome and psoriatic arthropathy). Clinical trials have been performed worldwide with various regimens and have not always led to conclusive results. In our experience long-term therapy with high doses of subcutaneously injected, recombinant interferon-alpha-2a in patients with HIV-associated Kaposi's sarcoma induces a remission or stabilization of the disease. In malignant melanoma a low response rate is obtained in metastatic disease with the use of interferon as a single therapeutic agent. Combined with other antitumor agents, however, interferon seems to be a useful drug. Excellent control of Behçet's disease...Continue Reading

References

Dec 1, 1979·The British Journal of Venereal Diseases·G M Scott, G W Csonka
Jan 10, 1986·Deutsche medizinische Wochenschrift·H Kirchner
Jan 1, 1985·The Journal of Investigative Dermatology·B BermanM Palladino
Jun 28, 1986·Lancet·J R Quesada, J U Gutterman
Oct 1, 1985·Journal of the American Academy of Dermatology·J M WolffE Abell
Aug 29, 1986·Deutsche medizinische Wochenschrift·G Fierlbeck, G Rassner
Jan 1, 1986·Archives of Dermatological Research·H J Schulze, G Mahrle
Oct 23, 1986·The New England Journal of Medicine·L J EronN Hien
Nov 1, 1986·The American Journal of Medicine·M S Roth, K A Foon
Sep 1, 1986·Journal of the American Academy of Dermatology·H T GreenwayC Nagi
Nov 14, 1986·Deutsche medizinische Wochenschrift·O Braun-FalcoC Schmoeckel
Mar 6, 1987·Deutsche medizinische Wochenschrift·U Elsässer-BeileB R Balda
Apr 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A RiosJ U Gutterman
Sep 15, 1985·American Journal of Obstetrics and Gynecology·S A GallK Trofatter
Apr 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F X RealS E Krown
Mar 1, 1985·Cancer·T J GarrettL Thomas
Jan 1, 1982·International Journal of Dermatology·B Berman, H M Frankfort
Jun 1, 1983·The Journal of Dermatology·M Niimura
Aug 1, 1984·Journal of the American Academy of Dermatology·E J AndrophyD R Lowy
Jan 12, 1984·The New England Journal of Medicine·J W CurranT J Spira
Jan 1, 1983·Acta Obstetricia Et Gynecologica Scandinavica·N EinhornH Strander
Jan 1, 1982·Journal of Interferon Research·G J PazinK Cantell
Feb 1, 1987·Cancer·J E Groopman
Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACS, J LINDENMANN

❮ Previous
Next ❯

Citations

Jan 1, 1990·Archives of Dermatological Research·U WollinaR Klinger
Mar 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Y Tong, S B Tucker
May 1, 1991·The British Journal of Dermatology·J M DurandM Mongin
Jan 1, 1991·The British Journal of Dermatology·F M SchaartC E Orfanos
Apr 1, 1991·International Journal of Dermatology·R Stadler, C Garbe
Mar 1, 1995·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·R T Brodell, D L Bredle
Jun 1, 1991·Journal of the American Academy of Dermatology·T A Luger, T Schwarz
Dec 17, 2008·Clinical and Experimental Dermatology·A B AksakalM Onder
Jul 14, 2010·International Journal of Dermatology·Issam HamadahAbdulmajeed Alajlan
Jun 1, 1992·The American Journal of Medicine·T J ReidH Ozer
Jun 19, 1998·Journal of the American Academy of Dermatology·A S Boyd, L E King
May 20, 1998·Dermatologic Clinics·R Stadler
Sep 7, 2012·Case Reports in Medicine·Esra GuneyHuseyin Bayramlar
May 27, 1999·The Journal of Dermatology·C DurusoyE Yilmaz
Jan 15, 1999·International Journal of Dermatology·D S Hurd, E T Conte
Oct 1, 1994·Journal of the American Academy of Dermatology·E AlpsoyE Başaran
Dec 1, 1993·Journal of the American Academy of Dermatology·S BeissertT Schwarz
Feb 6, 2004·Dermatologic Therapy·Patricia T Ting, Marlene T Dytoc
Oct 2, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Brian A Baldo
Jul 21, 2006·The Journal of Dermatological Treatment·Emel Bulbul BaskanSemra Toker
Jan 1, 1992·The Annals of Pharmacotherapy·J F BrowderF P Flowers
Dec 1, 1990·The Journal of Investigative Dermatology·R D GransteinE P Amento

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

JAMA : the Journal of the American Medical Association
S BaronT K Hughes
Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer
C Garbe
Journal of the American Academy of Dermatology
K B Yancey, J G Smith
© 2022 Meta ULC. All rights reserved