PMID: 9181464May 1, 1997Paper

Interferons suppress mitochondrial gene transcription by depleting mitochondrial transcription factor A (mtTFA)

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
H InagakiY Kitagawa

Abstract

Mitochondrial gene transcription activity in organello was suppressed after culturing HeLa cells with 1000 U/ml of interferon-alpha (IFN-alpha) or IFN-gamma for 18 h. The suppression was associated with reduced levels of mitochondrial gene transcripts. Northern blot analysis of HeLa cell RNA showed marked reduction of the mRNA encoding for mitochondrial transcription factor A (mtTFA). Immunoblotting with antiserum directed against recombinant mtTFA showed a reduced level of the protein as well. Consistently, gel-retardation assay of mitochondrial extract showed reduced level of functional mtTFA, which is known to bind to both heavy and light strand promoters of bidirectionally transcribed mitochondrial DNA. We suggest that depletion of mtTFA is a pathway through which IFNs depress the mitochondrial respiration.

References

Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·I M Kerr, R E Brown
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jan 1, 1991·Experimental Cell Research·T Kadowaki, Y Kitagawa
Jan 1, 1991·Annual Review of Cell Biology·D A Clayton
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C AbateT Curran
Aug 1, 1988·Molecular and Cellular Biology·R P Fisher, D A Clayton
Apr 9, 1981·Nature·S AndersonI G Young

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Citations

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Jul 20, 2011·Antioxidants & Redox Signaling·Amal ChoumarAbdellah Mansouri
Sep 7, 2011·Drug Metabolism Reviews·Dominique PessayreAbdellah Mansouri
Jul 21, 2000·DNA Sequence : the Journal of DNA Sequencing and Mapping·H InagakiT Saito
Jan 27, 2006·Molecular Biology of the Cell·Olga MoiseevaGerardo Ferbeyre
Feb 18, 2006·Developmental Medicine and Child Neurology·Christine BarnériasPascale de Lonlay
Dec 6, 2001·Diabetes Research and Clinical Practice·Y S ChoiY K Pak
Nov 10, 2000·Biochimica Et Biophysica Acta·K H KainN K Herzog
Sep 7, 2000·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·L PolimenoA Francavilla
Jan 28, 2009·Journal of Neuroimmunology·Joerg-Patrick Stübgen
May 16, 2009·Journal of Neuroimmunology·Joerg-Patrick Stübgen

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