Interfractional reproducibility of lung tumor location using various methods of respiratory motion mitigation

International Journal of Radiation Oncology, Biology, Physics
George StarkschallRadhe Mohan

Abstract

To determine interfractional reproducibility of the location of lung tumors using respiratory motion mitigation. Free-breathing four-dimensional computed tomography (CT) data sets and CT data sets during breath hold were acquired weekly for 17 patients undergoing treatment for non-small-cell lung cancer. Distances between the center of the gross tumor volume (GTV) and a reproducible bony reference point under conditions of breath hold on end inspiration (EI) and end expiration (EE) and during free breathing on the 0% phase (corresponding to EI) and 50% phase (corresponding to EE) were analyzed for interfractional reproducibility. Systematic uncertainties in tumor location were determined as the difference in distance between the GTV center on the first CT data set and the mean location of GTV centers on the subsequent data sets. Random uncertainties in tumor location were determined as the standard deviation of the distances between the GTV centers and the bony reference points. Margins to account for systematic and random interfractional variations were estimated based on these uncertainties. Mean values of interfractional setup uncertainties were as follows: systematic uncertainties--EI, 0.3 cm; EE, 0.2 cm; 0% phase, 0.3 cm; ...Continue Reading

References

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Nov 21, 2008·Journal of Applied Clinical Medical Physics·Christopher NelsonGeorge Starkschall

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Citations

Oct 22, 2013·Journal of Radiation Research·Shinichiro MoriGeorge T Y Chen
Mar 14, 2014·Practical Radiation Oncology·Hong-Wei LiuHarold Lau
Oct 1, 2011·Cancer Science·Hiroki ShiratoKikuo Umegaki
Jan 10, 2013·Asia-Pacific Journal of Clinical Oncology·Eric HauRoland Yeghiaian Alvandi
Feb 25, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Judit Boda-HeggemannHelen McNair
Oct 25, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eelco LensArjan Bel
Mar 17, 2017·Journal of Applied Clinical Medical Physics·Evangelia KazaMartin O Leach
Feb 12, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yang LiTatsuya Ohno

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