Intergenerational accumulation of impairments in maternal behavior following postnatal social stress.

Psychoneuroendocrinology
Benjamin C NephewChristopher A Murgatroyd

Abstract

Early adversity such as depressed maternal care can have long-term physiological and behavioral effects on offspring and future generations. Exposure to chronic social stress (CSS), an ethologically model of postpartum depression and anxiety, during lactation impairs maternal care and exerts similar effects on the F1 dam offspring of the stressed F0 dams. These changes associate with increased corticosterone and neuroendocrine alterations. CSS F2 offspring further display decreased social behavior as juveniles and adults and decreased basal levels of corticosterone. This current study investigates the intergenerational inheritance of alterations in maternal behavior in F2 CSS dams together with neuroendocrine and immune markers to explore whether aspects of maternal behavior are intergenerationally inherited through immune and neuroendocrine mechanisms. We find that defects in maternal care behavior persist into the F2 generation with F2 dams exhibiting a pervasively depressed maternal care and increased restlessness throughout lactation. This occurs together with reduced basal cortisol (in contrast to an increase in F1 dams), a lack of changes in neuroendocrine gene expression, and reduced serum ICAM-1 (intercellular adhesion ...Continue Reading

Citations

Jun 18, 2019·Developmental Psychobiology·Vasiliy V ReshetnikovNatalia P Bondar
Dec 17, 2018·Archives of Women's Mental Health·Caitlin Post, Benedetta Leuner
Jul 30, 2017·Brain Sciences·Alexandria Hicks-NelsonBenjamin C Nephew
Mar 20, 2019·Journal of Neuroendocrinology·Florent PittetBenjamin C Nephew
Apr 4, 2019·The Behavioral and Brain Sciences·Benjamin C NephewHudson P Santos
May 6, 2021·Translational Psychiatry·Or BursteinRavid Doron
Mar 10, 2021·The European Journal of Neuroscience·Reema AlyamaniChris Murgatroyd
Aug 29, 2021·Behavioural Brain Research·Rachel SchroederHanna E Stevens

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BETA
PCR
ELISA

Software Mentioned

ODLog
Pyro Q - CpG
xPONENT

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