Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and environment. Here, we review recent work on the molecular mechanisms by which 'epigenetic' information is transmitted between generations over different timescales, and the importance of this information for development and physiology.
Caenorhabditis elegans DNA does not contain 5-methylcytosine at any time during development or aging
MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans
Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation
Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans
DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes
Transmission dynamics of heritable silencing induced by double-stranded RNA in Caenorhabditis elegans
Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice
A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory
The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals
Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells
Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint
Transgenerational effects of parental larval diet on offspring development time, adult body size and pathogen resistance in Drosophila melanogaster
Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression
tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma
Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state
Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation
Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content
Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development
The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression
Reduction in maternal Polycomb levels contributes to transgenerational inheritance of a response to toxic stress in flies
Delayed development induced by toxicity to the host can be inherited by a bacterial-dependent, transgenerational effect
Cytosine DNA methylation is found in Drosophila melanogaster but absent in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and other yeast species
Epistatic interaction of genetic depression risk variants in the human subgenual cingulate cortex during memory encoding
Reduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutants
In utero undernutrition in male mice programs liver lipid metabolism in the second-generation offspring involving altered Lxra DNA methylation
Soma-to-germline transmission of RNA in mice xenografted with human tumour cells: possible transport by exosomes
In utero effects. In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism
Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during development
Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations
Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans
The Nrde Pathway Mediates Small-RNA-Directed Histone H3 Lysine 27 Trimethylation in Caenorhabditis elegans
Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans
Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress
A transgenerational role of the germline nuclear RNAi pathway in repressing heat stress-induced transcriptional activation in C. elegans
A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans
Transgenerational programming of longevity and reproduction by post-eclosion dietary manipulation in Drosophila
An Abundant Class of Non-coding DNA Can Prevent Stochastic Gene Silencing in the C. elegans Germline
Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs
Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance
Environmental stresses induce transgenerationally inheritable survival advantages via germline-to-soma communication in Caenorhabditis elegans
Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in Caenorhabditis elegans
The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans
A critical assessment of the "sterile womb" and "in utero colonization" hypotheses: implications for research on the pioneer infant microbiome
Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory
Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C. elegans Germline
Transgenerational Sterility of Piwi Mutants Represents a Dynamic Form of Adult Reproductive Diapause
RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs
The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1
tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner.
Transgenerational Effects of Extended Dauer Diapause on Starvation Survival and Gene Expression Plasticity in Caenorhabditis elegans
Small RNAs Gained during Epididymal Transit of Sperm Are Essential for Embryonic Development in Mice.
Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis
Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health
Monitoring of switches in heterochromatin-induced silencing shows incomplete establishment and developmental instabilities
Intrauterine Growth Restriction Programs Intergenerational Transmission of Pulmonary Arterial Hypertension and Endothelial Dysfunction via Sperm Epigenetic Modifications
Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling
Epigenetic control of exercise adaptations in the equine athlete: Current evidence and future directions.
Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells.
Long-term and transgenerational phenotypic, transcriptional and metabolic effects in rabbit males born following vitrified embryo transfer
Using asexual vertebrates to study genome evolution and animal physiology: Banded (Fundulus diaphanus ) x Common Killifish (F. heteroclitus ) hybrid lineages as a model system
Paternal Contributions to Offspring Health: Role of Sperm Small RNAs in Intergenerational Transmission of Epigenetic Information
Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms
Long-Term Effects Following Fresh/Vitrified Embryo Transfer Are Transmitted by Paternal Germline in a Large Size Rabbit Cohort
Intermittent Hypoxia Promotes Functional Neuroprotection from Retinal Ischemia in Untreated First-Generation Offspring: Proteomic Mechanistic Insights.
Diet-induced DNA methylation within the hypothalamic arcuate nucleus and dysregulated leptin and insulin signaling in the pathophysiology of obesity
Short-term heritable variation overwhelms 200 generations of mutational variance for metabolic traits in Caenorhabditis elegans.
Intergenerational microplastics impact the intertidal barnacle Amphibalanus amphitrite during the planktonic larval and benthic adult stages
Ameliorative effect of recombinant human lactoferrin on the premature ovarian failure in rats after cyclophosphamide treatments.
Synthetic female gonadal hormones alter neurodevelopmental programming and behavior in F1 offspring.
Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations.
Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans
Metabolic diseases affect male reproduction and induce signatures in gametes that may compromise the offspring health
N6-methyldeoxyadenine and histone methylation mediate transgenerational survival advantages induced by hormetic heat stress.
Intergenerational effects of pre-pregnancy chronic lipopolysaccharide from Porphyromonas gingivalis on the learning, memory and seizure susceptibility of offspring.
Dealing with predictable and unpredictable temperatures in a climate change context: the case of parasitoids and their hosts.
Pathogenic Infection in Male Mice Changes Sperm Small RNA Profiles and Transgenerationally Alters Offspring Behavior
Microbiota, Epigenetics, and Trained Immunity. Convergent Drivers and Mediators of the Asthma Trajectory from Pregnancy to Childhood.
Stress-induced transcriptional memory accelerates promoter-proximal pause release and decelerates termination over mitotic divisions.
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