Intergenerational Cohort Study of Preterm and Small-for-Gestational-Age Birth in Twins and Singletons

Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies
Marie BladhG Sydsjö

Abstract

To date, several studies have investigated the intergenerational effect of preterm and small-for-gestational-age (SGA) births. However, most studies excluded both twin mothers and twin offspring from the analyses. Thus, the objective of this study was to investigate the intergenerational effect of preterm birth and SGA births among twins and singletons. A prospective population-based register study of mother-firstborn offspring pairs recorded in the Swedish Medical Birth Register was performed. The study included 4,073 twins and 264,794 singletons born from 1973-1983 and their firstborns born from 1986-2009. Preterm birth was defined as birth at <37 weeks of gestation, and SGA as birth weight <2 standard deviations of the Swedish standard. Logistic regressions were performed to estimate the intergenerational effect of each birth characteristic. Adjustments were made for maternal grandmothers' and mothers' socio-demographic factors, in addition to maternal birth characteristics. Among mothers born as singletons, being born preterm was associated with an increased risk of delivering a preterm child (adjusted odds ratio (OR) 1.39, 95% Confidence Interval (CI) = 1.29-1.50), while being born SGA increased the likelihood of having an...Continue Reading

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Citations

Jan 17, 2016·BMC Pregnancy and Childbirth·Caroline LilliecreutzAnn Josefsson
Nov 1, 2017·American Journal of Epidemiology·Marius Lahti-PulkkinenRebecca M Reynolds

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