Intergenerational differences in the effects of transcatheter closure of atrial septal defects on cardiac function

Journal of cardiology
Hideki TashiroYouzou Teramachi

Abstract

Little is known regarding intergenerational differences in the effects of atrial sepal defect (ASD) closure on the left heart. We therefore analyzed age-related serial changes in the left heart following ASD closure. We studied 50 patients with an isolated ASD who underwent successful transcatheter closure using Amplatzer septal occluders (St. Jude Medical, Little Canada, MN, USA) between June 2007 and June 2013. Patients were divided into three age groups: young patients aged ≤17 years; middle-aged patients aged 18-50 years; and older patients aged >50 years. Multi-modal echocardiographic studies with different views were performed before and at 1 day, 1-3 months, and 6-12 months after ASD closure. Echocardiographic variables were compared among the groups at different time points after closure. Left ventricular end-diastolic and end-systolic volume indices (EDVI and ESVI) in the older group were significantly smaller than those in the other groups before closure. EDVI and ESVI increased with time after closure in all groups with stable ejection fractions. However, EDVI and ESVI remained significantly smaller in the older group compared with the other groups. There was a significant interaction among the age groups only in ter...Continue Reading

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.