Intergenerational Influence of Paternal Obesity on Metabolic and Reproductive Health Parameters of the Offspring: Male-Preferential Impact and Involvement of Kiss1-Mediated Pathways

Endocrinology
Miguel A Sánchez-GarridoM Tena-Sempere

Abstract

Obesity and its comorbidities are reaching epidemic proportions worldwide. Maternal obesity is known to predispose the offspring to metabolic disorders, independently of genetic inheritance. This intergenerational transmission has also been suggested for paternal obesity, with a potential negative impact on the metabolic and, eventually, reproductive health of the offspring, likely via epigenetic changes in spermatozoa. However, the neuroendocrine component of such phenomenon and whether paternal obesity sensitizes the offspring to the disturbances induced by high-fat diet (HFD) remain poorly defined. We report in this work the metabolic and reproductive impact of HFD in the offspring from obese fathers, with attention to potential sex differences and alterations of hypothalamic Kiss1 system. Lean and obese male rats were mated with lean virgin female rats; male and female offspring were fed HFD from weaning onward and analyzed at adulthood. The increases in body weight and leptin levels, but not glucose intolerance, induced by HFD were significantly augmented in the male, but not female, offspring from obese fathers. Paternal obesity caused a decrease in luteinizing hormone (LH) levels and exacerbated the drop in circulating t...Continue Reading

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Citations

Apr 24, 2018·Clinical Endocrinology·Mathis Grossmann
Jul 28, 2018·Biology of Reproduction·Joanna H SliwowskaManuel Tena-Sempere
Feb 16, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thais de Castro BarbosaJuleen R Zierath
Jan 16, 2020·Journal of Developmental Origins of Health and Disease·Leonardo Toshio OshioVera Maria Peters
Jul 6, 2020·Nature Reviews. Endocrinology·Ben Bar-SadehPhilippa Melamed
Dec 4, 2020·Physiological Reviews·Daniel J HoffmanDaniel B Hardy
May 27, 2021·Reviews in Endocrine & Metabolic Disorders·Débora Juana CohenVanina Gabriela Da Ros
Aug 28, 2021·Critical Reviews in Food Science and Nutrition·Marcela Nascimento SertorioLuciana Pellegrini Pisani

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