Intergenerational response of steroidogenesis-related genes to maternal malnutrition

Journal of Developmental Origins of Health and Disease
Abdel Halim HarrathAbdelhabib Semlali

Abstract

We sought to examine whether rat maternal food restriction (MFR) affects the expression of steroidogenesis-related genes Cyp19, Cyp17a1, Insl3 and Gdf-9 in the ovaries of offspring from the first (FRG1) and second (FRG2) generations at pre-pubertal age (week 4) and during adulthood (week 8). At week 4, MFR significantly increased the expression of RNAs for all analyzed genes in both FRG1 and FRG2 females, which may indicate that MFR affects the onset of the reproductive lifespan, by inducing early pubertal onset. At week 8, the Cyp19 gene was still upregulated in MRF-subjected animals (Cyp19: P=0.0049 and P=0.0508 in FRG1 and FRG2, respectively), but MFR induced a significant decrease in Cyp17 and Gdf-9 gene expression in the offspring of both FRG1 and FRG2 females when compared with the controls (Cyp17: P=0.0018 and P=0.0016, respectively; Gdf-9: P=0.0047 and P=0.0023, respectively). This suggests that females at week 8, which should normally be in their optimal reproductive capacity, experience premature ovarian aging. At week 4, the activation of Cyp19 and Cyp17 was higher in the FRG1 ovaries than in the FRG2 ovaries, whereas the extent of Insl3 and Gdf-9 activation was lower in the FRG1 ovaries. This may indicate that FRG2 ...Continue Reading

References

Dec 1, 1987·The Journal of Clinical Endocrinology and Metabolism·S J RichardsonJ F Nelson
Aug 26, 1998·Journal of Reproduction and Fertility·A A MurrayN Spears
Oct 13, 2001·Reproduction : the Official Journal of the Society for the Study of Fertility·D Meikle, M Westberg
Jan 12, 2002·The Journal of Endocrinology·K J TurnerP T K Saunders
Jan 26, 2002·British Medical Bulletin·D J Barker
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·John J EppigFrank L Pendola
Mar 26, 2002·Climacteric : the Journal of the International Menopause Society·H G BurgerD M Robertson
Jul 20, 2002·Trends in Endocrinology and Metabolism : TEM·William E RaineyJ Ian Mason
Jul 24, 2002·Biology of Reproduction·Ursula A VittAaron J W Hsueh
Feb 8, 2003·Molecular and Cellular Endocrinology·Walter L Miller
Apr 22, 2003·American Journal of Human Biology : the Official Journal of the Human Biology Council·Peter T Ellison
Apr 9, 2004·The Journal of Clinical Endocrinology and Metabolism·John F RandolphRoderick J Little
Apr 28, 2004·Trends in Endocrinology and Metabolism : TEM·Peter D Gluckman, Mark A Hanson
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kazuhiro KawamuraAaron J W Hsueh
Nov 13, 2004·Psychological Bulletin·Bruce J Ellis
Jul 5, 2005·Mechanisms of Ageing and Development·Susan E Ozanne, C Nicholas Hales
May 23, 2006·Molecular and Cellular Endocrinology·P D Gluckman, M A Hanson
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Grazyna JasienskaPeter T Ellison
Oct 21, 2006·Biochemical Society Transactions·M S Martin-Gronert, S E Ozanne
Jan 8, 2008·Human Reproduction Update·Robert B GilchristJeremy G Thompson
Mar 11, 2008·Trends in Endocrinology and Metabolism : TEM·Peter D GluckmanHamish G Spencer
Jun 3, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Laura F PisaniFulvio Gandolfi
Jul 3, 2008·The Journal of Clinical Endocrinology and Metabolism·MaryFran R SowersJohn F Randolph
Jul 24, 2008·The Journal of Clinical Endocrinology and Metabolism·MaryFran R SowersJohn F Randolph
Jan 7, 2009·Seminars in Cell & Developmental Biology·John Godwin
Jul 11, 2009·Journal of Ovarian Research·Makoto OrisakaFumikazu Kotsuji
Oct 22, 2010·Human Reproduction Update·Deborah M SlobodaRoger Hart
Dec 9, 2010·Reproductive Biology and Endocrinology : RB&E·Carol B HannaXuemei Wu

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