Intergenerational Sex-Specific Transmission of Maternal Social Experience

Scientific Reports
Jamshid FarajiGerlinde A S Metz

Abstract

The social environment is a major determinant of individual stress response and lifetime health. The present study shows that (1) social enrichment has a significant impact on neuroplasticity and behaviour particularly in females; and (2) social enrichment in females can be transmitted to their unexposed female descendants. Two generations (F0 and F1) of male and female rats raised in standard and social housing conditions were examined for neurohormonal and molecular alterations along with changes in four behavioural modalities. In addition to higher cortical neuronal density and cortical thickness, social experience in mothers reduced hypothalamic-pituitary-adrenal (HPA) axis activity in F0 rats and their F1 non-social housing offspring. Only F0 social mothers and their F1 non-social daughters displayed improved novelty-seeking exploratory behaviour and reduced anxiety-related behaviour whereas their motor and cognitive performance remained unchanged. Also, cortical and mRNA measurements in the F1 generation were affected by social experience intergenerationally via the female lineage (mother-to-daughter). These findings indicate that social experience promotes cortical neuroplasticity, neurohormonal and behavioural outcomes,...Continue Reading

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Citations

Jan 17, 2020·Genes, Brain, and Behavior·Hadj S AouedBrian G Dias
Jul 1, 2021·Biology of Reproduction·Anatoly E MartynyukTimothy E Morey
Jan 21, 2022·Developmental Psychobiology·Annakarina MundorfNadja Freund

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Methods Mentioned

BETA
X-ray
enzyme-linked immunosorbent assay
Assay
histone acetylation

Software Mentioned

SPSS
HVS Image
ImageJ
SINA Motiongraph

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