Intergenerational Transmission of Gene Regulatory Information in Caenorhabditis elegans

Trends in Genetics : TIG
Olga Minkina, Craig P Hunter

Abstract

Epigenetic mechanisms can stably maintain gene expression states even after the initiating conditions have changed. Often epigenetic information is transmitted only to daughter cells, but evidence is emerging, in both vertebrate and invertebrate systems, for transgenerational epigenetic inheritance (TEI), the transmission of epigenetic gene regulatory information across generations. Each new description of TEI helps uncover the properties, molecular mechanisms and biological roles for TEI. The nematode Caenorhabditis elegans has been particularly instrumental in the effort to understand TEI, as multiple environmental and genetic triggers can initiate an epigenetic signal that can alter the expression of both transgenes and endogenous loci. Here, we review recent studies of TEI in C. elegans.

Citations

Dec 19, 2018·Nature Cell Biology·Sarah-Lena OffenburgerBen Lehner
Dec 18, 2018·Inflammation and Regeneration·Saya KishimotoEisuke Nishida
Feb 6, 2020·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Steven Q Irvine
Nov 15, 2018·Nature Reviews. Molecular Cell Biology·Ksenia SkvortsovaOzren Bogdanović
Feb 24, 2019·Environmental Science and Pollution Research International·Shuhao DaiLihong Yin
Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Faye A Baxter, Amanda J Drake
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Abhimanyu DasGuptaArneet L Saltzman
Apr 15, 2020·Ecotoxicology and Environmental Safety·Ana De la Parra-GuerraJesus Olivero-Verbel
Nov 19, 2021·Biochemical Genetics·Meenu Ghai, Farzeen Kader

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