PMID: 11933067Apr 5, 2002Paper

Interhelical hydrogen bonds and spatial motifs in membrane proteins: polar clamps and serine zippers

Proteins
L Adamian, Jie Liang

Abstract

Polar and ionizable amino acid residues are frequently found in the transmembrane (TM) regions of membrane proteins. In this study, we show that they help to form extensive hydrogen bond connections between TM helices. We find that almost all TM helices have interhelical hydrogen bonding. In addition, we find that a pair of contacting TM helices is packed tighter when there are interhelical hydrogen bonds between them. We further describe several spatial motifs in the TM regions, including "Polar Clamp" and "Serine Zipper," where conserved Ser residues coincide with tightly packed locations in the TM region. With the examples of halorhodopsin, calcium-transporting ATPase, and bovine cytochrome c oxidase, we discuss the roles of hydrogen bonds in stabilizing helical bundles in polytopic membrane proteins and in protein functions.

References

Oct 25, 1990·Nucleic Acids Research·T D Schneider, R M Stephens
Aug 7, 1990·Biochemistry·K A Dill
May 20, 1994·Journal of Molecular Biology·I K McDonald, J M Thornton
Feb 1, 1996·Journal of Molecular Graphics·R KoradiK Wüthrich
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·S O Shan, D Herschlag
Apr 4, 1997·Science·K R MacKenzieD M Engelman
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Sep 23, 1997·Journal of Molecular Biology·K G FlemingD M Engelman
Nov 20, 1997·The Journal of Biological Chemistry·D H MacLennanN M Green
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·C OstermeierH Michel
May 16, 1998·The Journal of Biological Chemistry·T Marti
Jul 11, 1998·Science·R B Gennis
Jan 27, 1999·Biochimica Et Biophysica Acta·I T Arkin, A T Brunger
Jul 2, 1999·Journal of Molecular Biology·J TsaiM Gerstein
Jul 20, 1999·Annual Review of Biophysics and Biomolecular Structure·S H White, W C Wimley
Jul 22, 1999·Biochemistry·T A Isenbarger, M P Krebs
Aug 24, 1999·Journal of Molecular Biology·H LueckeJ K Lanyi
Feb 3, 2000·Nature Structural Biology·C ChomaW F DeGrado
Aug 5, 2000·Science·K PalczewskiM Miyano
Dec 2, 2000·Nature Structural Biology·M M Zhou
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·H GratkowskiW F DeGrado
Jun 28, 2001·Nature Structural Biology·A G TherienC M Deber
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·A SenesD M Engelman
Aug 24, 2001·Journal of Molecular Biology·L Adamian, J Liang

❮ Previous
Next ❯

Citations

Jan 23, 2003·Biopolymers·Anthony W PartridgeCharles M Deber
Jan 13, 2006·Journal of Molecular Modeling·Camelia Baleanu-Gogonea, Sadashiva Karnik
Mar 17, 2004·Journal of Molecular Biology·Wei LiuSteven O Smith
Mar 5, 2003·Journal of Molecular Biology·Larisa AdamianJie Liang
Mar 29, 2003·Journal of Molecular Biology·Nathan O StitzielJie Liang
Apr 23, 2003·Journal of Molecular Biology·Bernhard LollJacek Biesiadka
Sep 2, 2003·Current Opinion in Structural Biology·A Rachael Curran, Donald M Engelman
Dec 10, 2002·Current Opinion in Chemical Biology·Jie Liang
Feb 16, 2005·Astrobiology·Andrew PohorilleMichael A Wilson
Oct 25, 2006·Bioinformatics·Anne E Counterman BurbaMark Gerstein
Aug 10, 2011·Genome Biology and Evolution·Yasuhiro KitazoeMasashi Tanaka
Sep 23, 2009·Acta Crystallographica. Section D, Biological Crystallography·Tarini Shankar GhoshRamasubbu Sankararamakrishnan
Mar 31, 2007·Science·Hang YinWilliam F DeGrado
Mar 13, 2012·Annual Review of Biophysics·James H Naismith, Ian R Booth
Jun 5, 2014·Annual Review of Biophysics·Karen G Fleming
Apr 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Prashen ChelikaniH Gobind Khorana
Jul 28, 2012·The Journal of Membrane Biology·Coral Del ValAna-Nicoleta Bondar
Jan 27, 2010·Cellular and Molecular Life Sciences : CMLS·Sebastian FiedlerSandro Keller
Nov 16, 2010·Current Opinion in Structural Biology·James U Bowie
Aug 18, 2009·Chemistry and Physics of Lipids·Natalie Bordag, Sandro Keller
Jul 1, 2005·Protein Science : a Publication of the Protein Society·Damien ThéveninClifford R Robinson
Mar 24, 2006·Proteins·Peter Werner HildebrandRobert Preissner
Sep 19, 2007·Proteins·Antonio J Martin-GalianoDmitrij Frishman
Dec 24, 2005·Proteins·Vladimir Yarov-YarovoyDavid Baker
Oct 9, 2007·Biophysical Journal·Peter Werner HildebrandRobert Preissner
Dec 20, 2011·Biochimica Et Biophysica Acta·Ana-Nicoleta Bondar, Stephen H White
Nov 5, 2011·Biochimica Et Biophysica Acta·Jie LiangMeishan Lin
Aug 18, 2004·Current Opinion in Structural Biology·Alessandro SenesWilliam F DeGrado
Mar 18, 2009·Biophysical Journal·Oznur TastanHagai Meirovitch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
A SenesD M Engelman
Proceedings of the National Academy of Sciences of the United States of America
H GratkowskiWilliam F Degrado
Proceedings of the National Academy of Sciences of the United States of America
F X ZhouD M Engelman
© 2022 Meta ULC. All rights reserved