Interhemispheric Plasticity following Intermittent Theta Burst Stimulation in Chronic Poststroke Aphasia

Neural Plasticity
Joseph C GriffisJerzy P Szaflarski

Abstract

The effects of noninvasive neurostimulation on brain structure and function in chronic poststroke aphasia are poorly understood. We investigated the effects of intermittent theta burst stimulation (iTBS) applied to residual language-responsive cortex in chronic patients using functional and anatomical MRI data acquired before and after iTBS. Lateralization index (LI) analyses, along with comparisons of inferior frontal gyrus (IFG) activation and connectivity during covert verb generation, were used to assess changes in cortical language function. Voxel-based morphometry (VBM) was used to assess effects on regional grey matter (GM). LI analyses revealed a leftward shift in IFG activity after treatment. While left IFG activation increased, right IFG activation decreased. Changes in right to left IFG connectivity during covert verb generation also decreased after iTBS. Behavioral correlations revealed a negative relationship between changes in right IFG activation and improvements in fluency. While anatomical analyses did not reveal statistically significant changes in grey matter volume, the fMRI results provide evidence for changes in right and left IFG function after iTBS. The negative relationship between post-iTBS changes in ...Continue Reading

References

Apr 1, 1978·Neurology·J P MohrK R Davis
Sep 1, 1976·Stroke; a Journal of Cerebral Circulation·P YarnellL Sobel
Oct 1, 1995·Annals of Neurology·P M PedersenT S Olsen
Nov 5, 1997·NeuroImage·K J FristonR J Dolan
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Apr 18, 2001·NeuroImage·D R GitelmanC J Price
Jul 7, 2001·Stroke; a Journal of Cerebral Circulation·F PulvermüllerE Taub
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Jan 25, 2005·Neuron·Ying-Zu HuangJohn C Rothwell
Mar 16, 2005·Brain and Language·Margaret A NaeserAlvaro Pascual-Leone
Jun 7, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andreas Bartels, Semir Zeki
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Mar 28, 2006·Brain and Language·W-D Heiss, A Thiel
Apr 28, 2006·Brain : a Journal of Neurology·Dorothee SaurCornelius Weiller
Jun 8, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alexander ThielWolf-Dieter Heiss
Jun 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Feb 27, 2007·Stroke; a Journal of Cerebral Circulation·Lutz WinhuisenWolf D Heiss
Mar 28, 2007·Journal of Neuroscience Methods·Marko Wilke, Karen Lidzba
Apr 5, 2007·Brain : a Journal of Neurology·N F DronkersE A Cabanis
Oct 30, 2007·Epilepsy & Behavior : E&B·Jerzy P SzaflarskiMagdalena Szaflarski
Dec 26, 2007·Magnetic Resonance Imaging·Mohamed L Seghier
Apr 16, 2008·NeuroImage·Kenneth P EatonScott K Holland
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dorothee SaurCornelius Weiller
Aug 19, 2009·Cerebral Cortex·Julius FridrikssonChris Rorden
Sep 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julius Fridriksson
Dec 9, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C H S BarwoodA Wong
Dec 18, 2010·Stroke; a Journal of Cerebral Circulation·Nora WeiduschatWolf Dieter Heiss
Aug 9, 2011·Current Biology : CB·Rachel HollandJennifer Crinion
Nov 22, 2011·Neuron·Jonathan D PowerSteven E Petersen
Jan 4, 2012·Archives of Physical Medicine and Rehabilitation·Dorothee Saur, Gesa Hartwigsen
Jan 4, 2012·Archives of Physical Medicine and Rehabilitation·Margaret A NaeserAlvaro Pascual-Leone
Jan 10, 2012·NeuroImage·Julius FridrikssonBo Cai
Jan 12, 2012·Restorative Neurology and Neuroscience·Jane B AllendorferJerzy P Szaflarski
Feb 7, 2012·NeuroImage·P RipollésA Rodriguez-Fornells

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Citations

Dec 17, 2016·Human Brain Mapping·Joseph C GriffisJerzy P Szaflarski
Dec 20, 2017·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Denise Y HarveyRoy H Hamilton
Oct 7, 2017·Frontiers in Human Neuroscience·Keith C DoddVivek Prabhakaran
May 22, 2018·Restorative Neurology and Neuroscience·Rodolphe NenertJerzy P Szaflarski
Nov 25, 2020·Expert Review of Neurotherapeutics·Shannon M Sheppard, Rajani Sebastian
Dec 22, 2020·Current Physical Medicine and Rehabilitation Reports·Bonnie L Breining, Rajani Sebastian
Mar 30, 2021·Current Physical Medicine and Rehabilitation Reports·Rachel FabianArgye E Hillis
Apr 17, 2021·Neuroscience and Biobehavioral Reviews·Sophie Arheix-ParrasBertrand Glize

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Clinical Trials Mentioned

NCT01512264

Software Mentioned

SPM12
gnb
MATLAB
SPM
min
gPPI for SPM
Statistical Parametric Mapping ( SPM12
MATLAB scripts
lesion
New Segment

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