Interhemispheric synchrony of slow oscillations of cortical blood volume and cytochrome aa3 redox state in unanesthetized rabbits

Brain Research
B A VernW H Schuette

Abstract

In order to study spontaneous, slow oscillations of regional oxidative metabolism and blood flow in the normal, unanesthetized cortex, adult rabbits were implanted with bilateral cortical windows and electrodes for polysomnography. Relative changes in the cortical intramitochondrial redox state of cytochrome aa3 (CYT) and blood volume (CBV) were monitored by dual-wavelength reflectance spectrophotometry. Continuous, non-stationary oscillations (< 0.5 Hz) of both CYT and CBV were observed during waking and non-REM sleep. Cross-correlation analysis revealed a predominant interhemispheric synchrony of these oscillations which were unrelated to the heart rate, breathing, or electrocorticogram pattern. These findings suggest a dynamic linkage of slowly varying metabolic and vascular processes between unanesthetized cortical regions of 50 mm2 surface area.

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Citations

May 8, 2013·PloS One·Basavaraju G SanganahalliSridhar S Kannurpatti
Nov 24, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sridhar S Kannurpatti
Jan 1, 2011·Brain Connectivity·Marcus E Raichle
Apr 3, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Masaki FukunagaJeff H Duyn
Apr 1, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Marcus E Raichle
Mar 7, 2014·Journal of Neurophysiology·A MitraM E Raichle
Aug 31, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anish Mitra, Marcus E Raichle
Aug 13, 2017·Journal of Biophotonics·Teemu MyllyläIgor Meglinski
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Aug 15, 2008·Journal of Neurophysiology·Dongyang ZhangMarcus E Raichle
Dec 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hellmuth Obrig, Arno Villringer
Jul 23, 2021·Science Advances·Ryan V RautMarcus E Raichle

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