Interhermispheric inhibition predicts anxiety levels in multiple sclerosis: A corticospinal excitability study

Brain Research
Moussa A ChalahSamar S Ayache

Abstract

Depression and anxiety stand among the most frequent and debilitating complaints in multiple sclerosis (MS) patients. Understanding their neurophysiological correlates might improve their management. To date, no single study has addressed this issue. Patients completed the Hospital Anxiety and Depression Scale (HADS). Transcranial magnetic stimulation (TMS) was performed to obtain the following corticospinal excitability measures: resting motor threshold, short-interval intracortical inhibition and facilitation, cortical silent period and interhemispheric inhibition (IHI). Anxiety and depression scores were the primary outcomes in the univariate analysis. When obtaining significant associations between anxiety/depression and TMS measures, a multivariate analysis was performed using stepwise linear regression with anxiety and depression scores employed separately as dependent variables and TMS measures, clinical and sociodemographic data as independent variables. Due to the small sample size and the large number of studied variables, only variables with p values <0.05 in the univariate analysis were included in the multivariate analysis. Fifty patients completed the study (n = 24 women). Their mean age was 51.82 ± 12.72 years. M...Continue Reading

Citations

Aug 1, 2020·Frontiers in Neurology·Mario Stampanoni BassiEnnio Iezzi
Mar 17, 2020·Multiple Sclerosis and Related Disorders·Moussa A ChalahSamar S Ayache

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