Interictal brain 5-HT1A receptors binding in migraine without aura: a 18F-MPPF-PET study

Cephalalgia : an International Journal of Headache
Amélie LotheFrançois Mauguière

Abstract

In this study we aimed to assess the brain distribution of 5-HT(1A) receptors in migraine patients without aura. Ten female migraine patients and 24 female healthy volunteers underwent magnetic resonance imaging and positron emission tomography using a radioligand antagonist of 5-HT(1A) receptors [4-(2'-methoxyphenyl)-1-[2'-(N-2-pirydynyl)-p-fluorobenzamido]-ethylpiperazine ((18)F-MPPF)]. A simplified reference tissue model was used to generate parametric images of 5-HT(1A) receptor binding potential (BP) values. Statistical Parametrical Mapping (SPM) analysis showed increased MPPF BP in posterior cortical areas and hippocampi bilaterally in patients compared with controls. Region of interest (ROI) analysis showed a non-significant trend in favour of a BP increase patients in cortical regions identified by the SPM analysis except in hippocampi, left parietal areas and raphe nuclei. During the interictal period of migraine patients without aura, the increase of MPPF BP in posterior cortical and limbic areas could reflect an increase in receptor density or a decrease of endogenous serotonin, which could explain their altered cortical excitability.

References

Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonR S Frackowiak
Oct 1, 1990·Cephalalgia : an International Journal of Headache·C A RibeiroT dos R de Macedo
Sep 1, 1989·Neurology·M D FerrariG W Bruyn
May 1, 1986·Annals of Neurology·B C HinerS J Peroutka
Sep 1, 1987·Headache·N H RaskinS Lamb
Jul 1, 1995·Nature Medicine·C WeillerH C Diener
Feb 1, 1997·Cephalalgia : an International Journal of Headache·A Panconesi, R Sicuteri
Dec 1, 1996·NeuroImage·A A Lammertsma, S P Hume
Aug 17, 1999·Current Opinion in Neurobiology·P Mason
Oct 26, 1999·Neurology·D C ChuganiH T Chugani
May 29, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J AfraJ Schoenen
Aug 30, 2000·Nuclear Medicine and Biology·L Lanfumey, M Hamon
Apr 11, 2001·Lancet·A BahraP J Goadsby
Sep 8, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MazziottaB Mazoyer
Feb 1, 2002·European Journal of Pharmacology·Maxime RicherPierre Blier
Jun 5, 2002·Current Opinion in Neurology·Nicola J Giffin, Holger Kaube
Jan 22, 2003·Cephalalgia : an International Journal of Headache·E M CassidyV O'Keane
Jun 14, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean SchoenenAlain Maertens de Noordhout
Dec 23, 2004·Headache·F VelosoC Toth
Feb 12, 2005·Brain : a Journal of Neurology·S K AfridiP J Goadsby
Aug 10, 2005·Archives of Neurology·Shazia K AfridiPeter J Goadsby
Jul 27, 2006·Headache·Andreas R Gantenbein, Peter S Sándor
Oct 17, 2006·Headache·Sandra W Hamelsky, Richard B Lipton
Jan 19, 2007·Psychotherapy and Psychosomatics·Giovanni Abbate-DagaLorenzo Pinessi
Mar 14, 2007·Journal of Neurology·Sigrid Schuh-HoferGuy Arnold
Sep 7, 2007·Brain Research·Ilkka K MartikainenAntti Pertovaara

❮ Previous
Next ❯

Citations

Jun 6, 2009·The Journal of Headache and Pain·Alessandro PanconesiLeonello Guidi
Feb 24, 2015·BioMed Research International·Andrej FabjanBojana Žvan
Mar 26, 2016·Cephalalgia : an International Journal of Headache·Marie DeenMessoud Ashina
Apr 22, 2015·The Journal of Headache and Pain·Yu-Chwen ChiuHung-Meng Huang
Sep 26, 2013·Cephalalgia : an International Journal of Headache·Jean Schoenen
Nov 3, 2010·Cephalalgia : an International Journal of Headache·G DemarquayP Ryvlin
Oct 22, 2014·Cephalalgia : an International Journal of Headache·Andrej FabjanMarjan Zaletel
Mar 21, 2013·Current Opinion in Neurology·Inga L Kröger, Arne May
Jun 16, 2011·Medicinal Research Reviews·Louise M PatersonGitte M Knudsen
Nov 29, 2016·Frontiers in Neuroscience·Dubravka Svob StracGiuseppe Di Giovanni
Feb 15, 2017·The Journal of Headache and Pain·Claudia Francesca GaspariniLyn Robyn Griffiths
May 21, 2019·Journal of Cellular and Molecular Medicine·Qing ZhangWeibo Liu
Nov 29, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Luc Zimmer, Didier Le Bars
Jun 20, 2020·Journal of Affective Disorders·Dong Hyun LeeMin Kyung Chu

❮ Previous
Next ❯

Software Mentioned

SAS®
SPM
SPM2

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
N HadjikhaniM A Moskowitz
Cephalalgia : an International Journal of Headache
G DemarquayPhilippe Ryvlin
© 2022 Meta ULC. All rights reserved