Interictal high frequency oscillations in an animal model of infantile spasms.

Neurobiology of Disease
James D FrostJohn W Swann

Abstract

While infantile spasms is the most common catastrophic epilepsy of infancy and early-childhood, very little is known about the basic mechanisms responsible for this devastating disorder. In experiments reported here, spasms were induced in rats by the chronic infusion of TTX into the neocortex beginning on postnatal days 10-12. Studies of focal epilepsy suggest that high frequency EEG oscillations (HFOs) occur interictally at sites that are most likely responsible for seizure generation. Thus, our goal was to determine if HFOs occurred and where they occurred in cortex in the TTX model. We also undertook multiunit recordings to begin to analyze the basic mechanisms responsible for HFOs. Our results show that HFOs occur most frequently during hypsarrhythmia and NREM sleep and are most prominent contralateral to the TTX infusion site in the homotopic cortex and anterior to this region in frontal cortex. While HFOs were largest and most frequent in these contralateral regions, they were also commonly recorded synchronously across multiple and widely-spaced recordings sites. The amplitude and spatial distribution of interictal HFOs were found to be very similar to the high frequency bursts seen at seizure onset. However, the latter...Continue Reading

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Citations

Aug 12, 2014·Brain Research·K Pardo-PeñaA Morales-Villagrán
Oct 3, 2014·BioMed Research International·Consuelo Ventura-Mejía, Laura Medina-Ceja
Nov 14, 2014·Science Translational Medicine·Alla KatsnelsonJohn W Swann
Jan 15, 2013·Brain & Development·Aristea S Galanopoulou
Jun 27, 2015·Chinese Medical Journal·Yan-Ping SunJun-Li Tai
Aug 22, 2016·Seminars in Pediatric Neurology·Li-Rong Shao, Carl E Stafstrom
Jul 8, 2017·Epilepsy Currents·Libor Velíšek
Nov 17, 2017·Journal of Neurophysiology·Min-Jee KimTae-Sung Ko
Apr 20, 2018·Epilepsy Currents·Chris G Dulla
Jan 16, 2020·Children·Remi JanicotCarl E Stafstrom
Oct 18, 2020·Annals of Neurology·Chih-Hong LeeJohn W Swann

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