PMID: 11605178Oct 18, 2001Paper

Interim analysis of a phase II study of induction weekly paclitaxel/carboplatin regimens followed by maintenance weekly paclitaxel for advanced and metastatic non-small cell lung cancer

Seminars in Oncology
Chandra P Belani

Abstract

This multi-institutional randomized phase II study was designed to compare the efficacy and toxicity of three different weekly paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) and carboplatin schedules in patients with advanced and metastatic non-small cell lung cancer. The second part of the trial evaluated the role of maintenance weekly paclitaxel for those with response or stable disease after 16 weeks of initial treatment. Patients in arm 1 received paclitaxel 100 mg/m(2)/wk for 3 weeks along with carboplatin (area under the curve of 6) on day 1 every 4 weeks. The treatment in arm 2 was the same as in arm 1 except that carboplatin was also administered weekly (area under the curve of 2) for 3 weeks. Patients in arm 3 received paclitaxel 150 mg/m(2)/wk and carboplatin (area under the curve of 2 per week) during the second 8-week cycle. The total duration of this initial therapy was 16 weeks. All regimens were well tolerated. Arm 1 has the best therapeutic index and will exceed the median survival seen in previous phase III trials with traditional schedules of paclitaxel and carboplatin.

Citations

May 18, 2004·Cancer Treatment Reviews·Hans Wildiers, Robert Paridaens
Feb 15, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M Rita MigliorinoOlga Martelli
Mar 14, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shinji AtagiMasanori Akira
Mar 28, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mark A SocinskiDavid Garfield
Dec 31, 2002·Critical Reviews in Oncology/hematology·Vicente AlberolaOscar Juan
Dec 31, 2002·Critical Reviews in Oncology/hematology·Paolo MarchettiCorrado Ficorella
Jan 8, 2004·Seminars in Thoracic and Cardiovascular Surgery·Sakkaraiappan Ramalingam, Chandra P Belani
Jan 30, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A J ten TijeJ Verweij
Sep 3, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T KasaiS Kohno
Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Corey J Langer
Sep 30, 2015·Cancer Chemotherapy and Pharmacology·Sameh MikhailTanios Bekaii-Saab
Jul 20, 2002·Current Opinion in Oncology·Louise Medley, Michael Cullen

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