Interim analysis of a randomized controlled trial comparing laparoscopic radiofrequency volumetric thermal ablation of uterine fibroids with laparoscopic myomectomy

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
B KrämerSara Y Brucker

Abstract

To compare 24-month patient-reported outcomes following laparoscopic radiofrequency volumetric thermal ablation (RFVTA) and laparoscopic myomectomy in patients with uterine fibroids. An interim analysis of 24-month follow-up data from a randomized controlled trial was performed at Tübingen University Women's Hospital between November 1, 2012 and May 30, 2015. Premenopausal patients, at least 18years of age, who were menstruating, were randomly assigned to be treated for symptomatic uterine fibroids with either RFVTA or laparoscopic myomectomy. The outcomes included in the present per-protocol analysis were patients' responses to validated questionnaires and long-term safety. The study enrolled 51 patients; 21 and 22 patients in the RFVTA and laparoscopic myomectomy groups, respectively, completed 24months of follow-up. Improvements in the severity of symptoms from baseline were reported by participants in both the RFVTA (P<0.001) and laparoscopic myomectomy groups (P=0.001). A significant improvement in health-related quality of life was observed in the laparoscopic myomectomy group (P=0.040); a non-significant improvement was recorded in the RFVTA group (P=0.083). A trocar-site hematoma occurred in one patient in the laparosco...Continue Reading

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Jan 30, 2020·The Cochrane Database of Systematic Reviews·Mostafa MetwallyAndrew W Horne
Nov 9, 2019·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Linda D BradleyLarry E Miller
Nov 15, 2016·Deutsches Ärzteblatt International·Klaus J Neis
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Aug 26, 2020·Journal of Minimally Invasive Gynecology·Adela G CopeElizabeth A Stewart
Sep 5, 2021·Reproductive Sciences·Jiahui ZhangBhuchitra Singh

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