Interim fluoro-2-deoxy-D-glucose-PET predicts response and progression-free survival in patients with Hodgkin lymphoma and HIV infection

AIDS
Jessica OkosunKate Cwynarski

Abstract

Interim PET scans in HIV-negative patients with Hodgkin lymphoma has emerged as one of the most important prognostic tools. However, equivalent studies in HIV-positive patients are yet to be performed. We evaluated the prognostic value of interim [18F]-fluoro-2-deoxy-D-glucose-PET (18F-FDG PET) after two or three cycles of chemotherapy using adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) with concomitant HAART in HIV-positive patients with Hodgkin lymphoma. Patients with advanced HIV-Hodgkin lymphoma (HIV-HL) from six UK centres were included. Interim PET scans after two or three cycles of ABVD (PET-2 or PET-3) were carried out. Prognostic analysis correlated the 2-year progression-free survival (PFS) rate with the interim PET result. Twenty-three evaluable patients were assessed, 21 achieved a negative interim PET and 22 achieved complete remission by computerized tomography scan criteria after ABVD therapy. After a median follow-up of 27 months (range 12-50), disease progression was seen in one patient. Treatment failure was seen in one of the two interim PET-positive patients and none of the interim PET-negative patients. The 2-year PFS for interim PET-positive patients was 50%, and 100% for interim PET-negative p...Continue Reading

References

Sep 25, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P HartmannV Diehl
Sep 27, 2003·Lancet·Alexander M ScharkoC David Pauza
Jul 27, 2006·AIDS·Eric A EngelsUNKNOWN HIV/AIDS Cancer Match Study
Jan 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonUNKNOWN International Harmonization Project on Lymphoma
Nov 29, 2007·Journal of Clinical Pathology·K L GroggA Dogan
Aug 22, 2008·Clinical Nuclear Medicine·Elinor GoshenItzchak Levy
Oct 2, 2008·HIV Medicine·B G GazzardUNKNOWN BHIVA Treatment Guidelines Writing Group
Apr 3, 2009·Current Opinion in HIV and AIDS·Antonino CarboneMichele Spina
Sep 23, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Meredith S ShielsCharles Poole
Dec 21, 2010·British Journal of Haematology·Andrea GallaminiUNKNOWN Gruppo Italiano Terapie Innovative nei Linfomi (GITIL)

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