Interim results of a real-world observational study of eribulin in soft tissue sarcoma including rare subtypes

Japanese Journal of Clinical Oncology
Eisuke KobayashiAkira Kawai

Abstract

Although eribulin is used to treat soft tissue sarcomas (STSs), treatment data for rare subtypes are limited. We conducted a post-marketing surveillance study to assess safety and efficacy of eribulin in STS patients stratified by subtype. Japanese patients (n = 256) with advanced or metastatic STS receiving eribulin treatment were monitored for treatment status, adverse events, diagnostic imaging, and clinical outcomes at 3 months and 1 year. Interim analysis was performed. Patients will be monitored up to 2 years. Interim analysis included 3-month (n = 255), imaging (n = 226), and 1-year (n = 105) data. STS subtype distribution was normal. Median number of eribulin cycles was 3.0 (range: 1-17 cycles). Among patients with imaging data, best overall tumor response (12 weeks) was partial response, 7.5% (n = 17); stable disease, 34.5% (n = 78); and stable disease ≥11 weeks, 10.2% (n = 23). Overall response rate (ORR), disease control rate (DCR), and clinical benefit rate (CBR) for all patients were 7.5%, 42.0% and 17.7%, respectively. ORR, DCR, and CBR were 10.3%, 32.0% and 16.5%, respectively, for patients with STS subtypes other than liposarcoma and leiomyosarcoma and included responses from patients with rare STS subtypes. Adv...Continue Reading

References

Apr 2, 2004·Nature Reviews. Cancer·Mary Ann Jordan, Leslie Wilson
Sep 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicolas PenelJean-Yves Blay
Mar 8, 2011·Lancet·Javier CortesUNKNOWN EMBRACE (Eisai Metastatic Breast Cancer Study Assessing Physician's Choice Versus E7389) investigators
Sep 23, 2011·The Lancet Oncology·Patrick SchöffskiUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC) Soft Tissue and Bone Sarcoma Group (STBSG)
Oct 13, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K AogiS Takashima
Dec 4, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jean-Yves BlayRobert G Maki
Apr 1, 2014·The Oncologist·Hyman MussJoyce O'Shaughnessy
Nov 22, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Makoto EndoTorsten O Nielsen
Aug 12, 2015·Marine Drugs·Umang SwamiSanjay Goel
Apr 12, 2016·Journal of breast cancer·Jungsil RoUNKNOWN Asian Working Group for Eribulin Clinical Guide
Feb 12, 2017·Cardiovascular Drugs and Therapy·John V McGowanDerek M Yellon
Feb 12, 2017·The Journal of Dermatology·Naoko WadaMasutaka Furue
May 5, 2017·Expert Opinion on Pharmacotherapy·Sheik Emambux, Antoine Italiano
May 30, 2017·Clinical Oncology : a Journal of the Royal College of Radiologists·H HatcherT Ajithkumar
Jun 3, 2017·BMC Medicine·Anna Maria FrezzaAlessandro Gronchi
Jun 18, 2017·Expert Review of Anticancer Therapy·Elisabetta SetolaRobin L Jones
Aug 11, 2017·Therapeutic Advances in Medical Oncology·Gino K InWilliam W Tseng
Aug 31, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George D DemetriSant Chawla
Jan 3, 2018·International Journal of Molecular Sciences·Alessandro De VitaToni Ibrahim
Feb 13, 2018·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shoichiro OhtaniNorikazu Masuda
May 13, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·Margaret von MehrenJillian L Scavone
May 18, 2018·Frontiers in Immunology·Remy ThomasJulie Decock

❮ Previous
Next ❯

Citations

Jan 23, 2020·Cancers·Kenji Nakano, Shunji Takahashi

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft

Clinical Trials Mentioned

NCT03058406
NCT03331250
NCT03245450
NCT02387125

Software Mentioned

ANNOUNCE
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.