PMID: 18418344Apr 18, 2008Paper

Interim within-season estimate of the effectiveness of trivalent inactivated influenza vaccine--Marshfield, Wisconsin, 2007-08 influenza season

MMWR. Morbidity and Mortality Weekly Report
Centers for Disease Control and Prevention (CDC)

Abstract

During clinical trials, the efficacy of vaccination with inactivated influenza vaccines for the prevention of serologically confirmed influenza infection has been estimated as high as 70%-90% among healthier adults. However, the effectiveness of annual influenza vaccination typically is lower during those influenza seasons when a suboptimal match between the vaccine strains and circulating influenza strains is observed. For example, in a 4-year randomized study of influenza vaccine among healthy persons aged 1-65 years, the predominant strain was drifted from the vaccine strain in 2 of the 4 years. Inactivated vaccine effectiveness (VE) against culture-confirmed influenza ranged from 71% to 79% when the vaccine and circulating strains were suboptimally matched to 74% to 79% when the matches were well matched. In contrast, a 2-year study of inactivated influenza vaccine among healthy adults aged 18-64 years found no measurable VE during a year when a poorly matched strain circulated, but found VE of 86% against laboratory-confirmed influenza during the following year when the vaccine and circulating strains were well matched. Although laboratory data on the antigenic characteristics of circulating influenza viruses compared with...Continue Reading

Citations

Mar 3, 2009·Science·Damian C EkiertIan A Wilson
Jun 16, 2009·Emerging Infectious Diseases·Rosemary ProffAnn-Christine Nyquist
Dec 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tamara K BerthoudSarah C Gilbert
Jul 9, 2011·Science·Damian C EkiertJaap Goudsmit
Jul 19, 2011·Emerging Infectious Diseases·James E FieldingHeath A Kelly
Sep 24, 2013·BMC Infectious Diseases·Silvia Jiménez-JorgeUNKNOWN Spanish Influenza Sentinel Surveillance System
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Dec 3, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Wei-Ju SuJen-Hsiang Chuang
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Mar 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrick J LillieSarah C Gilbert
Apr 27, 2017·Influenza and Other Respiratory Viruses·Ting F LeungPaul K S Chan
Dec 29, 2013·Clinical and Vaccine Immunology : CVI·Serge DurviauxKarl Walravens

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