Interindividual and Intraindividual Variation of Methylphenidate Concentrations in Serum and Saliva of Patients With Attention-Deficit/Hyperactivity Disorder

Therapeutic Drug Monitoring
Joshua PreiskornMonica Biscaldi

Abstract

Therapeutic drug monitoring is becoming increasingly important in psychiatric therapy, especially in children. However, for several reasons, it cannot yet be implemented as a daily routine in clinical or outpatient settings. To evaluate new, noninvasive procedures, blood and saliva (oral fluid) samples were collected from patients with attention-deficit/hyperactivity disorder (ADHD) who were also being administered methylphenidate (MPH). The study's main purposes were to correlate MPH concentrations in serum and saliva between subjects and to analyze intraindividual variation of serum concentration. Thirty-six patients with ADHD (27 children and 9 adults) on MPH medication were included for drug analysis. MPH and its major metabolite ritalinic acid were quantified using liquid chromatography-tandem mass spectrometry measurements. The following correlations were investigated: (1) between drug concentrations in serum and saliva, and (2) between pH value and saliva to serum concentration ratio. Furthermore, the mean intraindividual MPH-concentration fluctuation in saliva under constant frame conditions was analyzed. After quantification, MPH concentrations were approximately 5 times higher in the saliva than in the serum, whereas ...Continue Reading

References

Jan 1, 1982·International Pharmacopsychiatry·P BaumannP K Le
Aug 1, 1993·Clinical Pharmacokinetics·G Cheymol
Oct 2, 1998·Journal of Clinical Pharmacy and Therapeutics·G DumortierK Degrassat
Oct 18, 2000·Therapeutic Drug Monitoring·I TsiropoulosN A Klitgaard
Oct 17, 2002·Drugs·Katherine A Lyseng-Williamson, Gillian M Keating
Jan 28, 2003·Therapeutic Drug Monitoring·Shellee A GrimRobert J Baumann
Mar 27, 2003·Therapeutic Drug Monitoring·Margareta ReisFinn Bengtsson
Oct 29, 2003·Pediatric Neurology·Michael V MilesRobert J Baumann
Dec 26, 2003·Pharmacotherapy·Melody RyanRobert J Baumann
Jan 25, 2005·Therapeutic Drug Monitoring·D J TouwUNKNOWN Cost-Effectiveness of Therapeutic Drug Monitoring Committee of the International Association for Therapeutic Drug Monitoring
Sep 8, 2005·Psychosomatics·Neil B SandsonKelly L Cozza
May 9, 2006·Critical Care Clinics·Bradley A BoucherJoseph M Swanson
May 29, 2007·Therapeutic Drug Monitoring·Oriano MecarelliNicola Vanacore
Nov 29, 2007·Therapeutic Drug Monitoring·Margareta ReisUNKNOWN Task Force for TDM of Escitalopram in Sweden
Jul 26, 2008·Journal of Analytical Toxicology·Kaarina LangelPirjo Lillsunde
Mar 25, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·Elizabeth PappadopulosJeffrey H Newcorn
Apr 14, 2009·Therapeutic Drug Monitoring·Simona PichiniRafael de laTorre
Apr 24, 2009·Clinical Pharmacokinetics·Offie P Soldin, Donald R Mattison
Jun 6, 2009·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Snezana DordevićTomislav Stojanović
Jun 12, 2009·Drug Metabolism Reviews·Ulrich Klotz
Nov 12, 2009·Clinical Pharmacokinetics·Shu-Feng Zhou
Jan 26, 2010·Forensic Science International : Synergy·E MarcheiS Pichini
Jun 7, 2011·Analytical and Bioanalytical Chemistry·Iolanda MazzucchelliEmilio Perucca
Dec 14, 2011·Biological Trace Element Research·Sindhu Jayasimha ShettyRaghavendra Bheemappa Nayak
May 15, 2013·Therapeutic Drug Monitoring·Danielle S FisherRobert J Flanagan
Dec 3, 2014·Toxicology Letters·Markus R MeyerHans H Maurer
Dec 3, 2014·Seizure : the Journal of the British Epilepsy Association·Rekha DwivediManjari Tripathi
Feb 19, 2015·Pharmacology Research & Perspectives·Elisabeth SchappererWerner Weitschies

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