Interindividual variations in the disposition and metabolism of ethanol in healthy men

Alcohol
A W Jones

Abstract

Forty-eight healthy men each drank a dose of ethanol, 0.68 g/kg of body weight, as neat whisky at about 09.00, after fasting overnight. The drink was finished within 20 min and the concentrations of ethanol in samples of capillary blood were determined at 30-60 min intervals for 7 hr. Rectilinear regression lines were fitted to the elimination phase of blood concentration time profiles and blood-ethanol parameters were calculated as described by Widmark. In 23, 14, 8 and 3 subjects the peak blood ethanol concentrations were reached at 30, 60, 90 and 120 min timed from starting to drink. The highest concentration of ethanol in blood was 0.92 +/- 0.022 mg/ml (mean +/- SE) and the coefficient of variation (CV) was 16.8%. The blood concentration of ethanol extrapolated to zero-time was 0.98 +/- 0.009 mg/ml (CV = 6.5%) and the apparent volume of distribution (Vd) was 0.695 +/- 0.0064 L/kg (CV = 6.4%). The rate of ethanol elimination from blood was 0.126 +/- 0.0018 mg/ml/hr (CV = 9.9%) and the body clearance was 87.5 +/- 1.1 mg/kg/hr (CV = 8.7%). The apparent volume of distribution of ethanol was inversely related to the subject's body weight (r = -0.59 +/- 0.118, p less than 0.001). The elimination rate from blood was lower in those...Continue Reading

References

Jan 1, 1976·Journal of Pharmaceutical Sciences·J G WagnerD J Weidler
May 15, 1973·Biochemical Pharmacology·R L Dedrick, D D Forrester
Apr 1, 1973·Journal of Pharmacokinetics and Biopharmaceutics·J G Wagner
Sep 5, 1970·British Medical Journal·J W DundeeM Isaac
Oct 15, 1983·Biochemical Pharmacology·S KeidingK Winkler
Jan 1, 1980·Alcoholism, Clinical and Experimental Research·P K Wilkinson
Oct 1, 1980·Alcoholism, Clinical and Experimental Research·P K WilkinsonL O Wilkin
Jan 1, 1981·Pharmacology & Therapeutics·J G Wagner
Jun 1, 1981·Journal of Pharmacokinetics and Biopharmaceutics·J L RheingoldP K Wilkinson
May 14, 1940·The Journal of Physiology·M G Eggleton

❮ Previous
Next ❯

Citations

May 26, 2009·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Ruth J BevanLeonard S Levy
Feb 6, 2009·Human Molecular Genetics·Andrew J BirleyJohn B Whitfield
May 1, 1994·British Journal of Clinical Pharmacology·A W Jones, K A Jönsson
Dec 1, 1995·Alcoholism, Clinical and Experimental Research·H R ThomassonT K Li
Oct 1, 1996·Alcoholism, Clinical and Experimental Research·T L WallC L Ehlers
Sep 26, 2000·Alcoholism, Clinical and Experimental Research·M S MumenthalerJ A Yesavage
Nov 10, 2009·Journal of Biomedical Optics·Trent D RidderBentley D Laaksonen
Dec 1, 2004·Clinical Pharmacokinetics·Alan Wayne JonesSven-Gunnar Olsson
May 23, 2014·Forensic Science International : Synergy·Kristof E MaudensHugo Neels
Mar 13, 2012·Pharmacology, Biochemistry, and Behavior·Christopher IrwinBen Desbrow
Jan 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carmen MartínezJosé A G Agúndez
Dec 21, 2002·British Journal of Clinical Pharmacology·H KlockhoffA W Jones
Aug 28, 2007·Journal of Forensic and Legal Medicine·C Roberts, S P Robinson
Jul 1, 1991·Medicine, Science, and the Law·A W Jones
Mar 1, 1987·Drug and Alcohol Dependence·A W Chan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.