Interlaboratory comparability of serum cotinine measurements at smoker and nonsmoker concentration levels: a round-robin study.

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
John Thomas BernertLoralie J Langman

Abstract

Cotinine, the primary proximate metabolite of nicotine, is commonly measured as an index of exposure to tobacco in both active users of tobacco and nonsmokers with possible exposure to secondhand smoke (SHS). A number of laboratories have implemented analyses for measuring serum cotinine in recent years, but there have been few interlaboratory comparisons of the results. Among nonsmokers exposed to SHS, the concentration of cotinine in blood can be quite low, and extensive variability in these measurements has been reported in the past. In this study, a group of seven laboratories, all experienced in serum cotinine analysis, measured eight coded serum pools with concentrations ranging from background levels of about 0.05 ng/ml to relatively high concentrations in the active smokers range. All laboratories used either gas-liquid chromatography with nitrogen-phosphorus detection or liquid chromatography with mass spectrometric detection. All seven laboratories reliably measured the cotinine concentrations in samples that were within the range of their methods. In each case, the results for the pools were correctly ranked in order, and no significant interlaboratory bias was observed at the 5% level of significance for results fro...Continue Reading

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Citations

Aug 15, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·T'ng Chang KwokTim Coleman
Mar 16, 2012·Environmental Health Perspectives·Germaine M Buck LouisKurunthachalam Kannan
May 11, 2011·International Journal of Environmental Research and Public Health·Jacques J Prignot
Aug 22, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Andrew W BergenGary E Swan
Jul 27, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Martin J JarvisJohn T Bernert
Dec 14, 2012·Tuberculosis and Respiratory Diseases·Soo-Taek UhChoon Sik Park
Jan 16, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Luis R VazUNKNOWN SNAP trial team
May 8, 2014·Journal of Exposure Science & Environmental Epidemiology·Britton TrabertGermaine M Buck Louis
May 18, 2016·Environmental Research·Megan E RomanoJoseph M Braun
Dec 22, 2016·Chemical Research in Toxicology·Peyton JacobTodd P Whitehead
Jan 11, 2018·International Journal of Environmental Research and Public Health·Julia C SchechterScott H Kollins
Aug 16, 2017·Annals of Work Exposures and Health·Sean SempleUNKNOWN Tobacco in Prisons (TIPs) Research Team
Nov 6, 2018·Journal of Analytical Toxicology·Honest AchilihuJohn T Bernert
May 20, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Suzaynn F SchickAruni Bhatnagar
Aug 31, 2018·Tobacco Control·Sean SempleJohn W Cherrie
Oct 4, 2020·International Journal of Environmental Research and Public Health·Robyn GildenAdam Spanier
Oct 28, 2020·Journal of Developmental Origins of Health and Disease·Blanche C IpJoseph M Braun
Feb 6, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Cindy M ChangDorothy K Hatsukami
Jun 2, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lanqing WangJames L Pirkle
Nov 30, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Albert J KsinanBernard F Fuemmeler
Jun 3, 2021·International Journal of Environmental Research and Public Health·Westley L FallavollitaBernard F Fuemmeler

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