Interlaboratory Coverage Test on Plant Food Bioactive Compounds and their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics

Metabolites
Ville Mikael KoistinenMaria Rosário Bronze

Abstract

Bioactive compounds present in plant-based foods, and their metabolites derived from gut microbiota and endogenous metabolism, represent thousands of chemical structures of potential interest for human nutrition and health. State-of-the-art analytical methodologies, including untargeted metabolomics based on high-resolution mass spectrometry, are required for the profiling of these compounds in complex matrices, including plant food materials and biofluids. The aim of this project was to compare the analytical coverage of untargeted metabolomics methods independently developed and employed in various European platforms. In total, 56 chemical standards representing the most common classes of bioactive compounds spread over a wide chemical space were selected and analyzed by the participating platforms (n = 13) using their preferred untargeted method. The results were used to define analytical criteria for a successful analysis of plant food bioactives. Furthermore, they will serve as a basis for an optimized consensus method.

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Citations

Apr 17, 2020·Antioxidants·Francisco J Olivas-AguirreAbraham Wall-Medrano
Feb 6, 2020·The Proceedings of the Nutrition Society·Christine MorandFrancisco Tomas-Barberan
Aug 20, 2020·Journal of Pharmaceutical and Biomedical Analysis·Özge Cansın ZekiEmirhan Nemutlu

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