PMID: 3383839Jan 1, 1988Paper

Interlaboratory evaluation of the C3H/10T1/2 cell transformation assay

Environmental and Molecular Mutagenesis
V C DunkelT P Cameron

Abstract

The C3H/10T1/2 transformation assay was evaluated for its responsiveness and interlaboratory reproducibility. Two laboratories participated in this study and tested a series of 46 chemicals. The majority of these chemicals were tested under code. Of the 46 chemicals tested, seven were determined to be active in both laboratories, and 14 were determined to be inactive. When the total number of chemicals is adjusted for assays considered "no test" in either one or both laboratories as well as for tests of chemicals yielding positive results in only one laboratory, reproducible responses were obtained for 21/35, or 60%, of the chemicals tested.

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J R Landolph, C Heidelberger
Apr 27, 1979·Biochemical and Biophysical Research Communications·J W GrishamD G Kaufman
Jan 1, 1985·Toxicology and Applied Pharmacology·P C BillingsJ R Landolph
Jan 1, 1982·Environmental Mutagenesis·Y Oshiro, P S Balwierz
Sep 1, 1981·Cancer Letters·D L Ragan, C J Boreiko

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Citations

Jun 1, 1994·Mutation Research·D McGregor
Jul 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A J Cohen, F J Roe
Jan 1, 1990·Environmental and Molecular Mutagenesis·R A LubetL M Schechtman
Jan 1, 1992·Environmental and Molecular Mutagenesis·C WestmorelandD Gatehouse
Jul 6, 2012·Alternatives to Laboratory Animals : ATLA·Robert D Combes
May 1, 1991·Archives of Biochemistry and Biophysics·L H PottengerC R Jefcoate

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