Interlaboratory reproducibility in reporting inadequate cervical smears--a multicentre multinational study

Cytopathology : Official Journal of the British Society for Clinical Cytology
S CiattoValeria Cocchi

Abstract

A set of 300 vaginal smears was interpreted by 13 cytologists from six European laboratories, who were requested to report inadequate and suboptimal smears. The set had been appropriately seeded to reach approximately 10% inadequate and 20% suboptimal smear frequency. According to the majority report, 230 smears were classified as adequate (76.7%), 43 as inadequate (14.3%), and 27 as suboptimal (9.0%). Agreement with the majority report ranged from 52% to 91% (average 78%). Kappa statistics for reporting inadequate smears showed a high level of agreement for five cytologists, and fair to good agreement for eight. In contrast, kappa statistics for reporting suboptimal smears showed fair to good agreement with the majority report only in five instances, whereas agreement was poor for eight cytologists. 'Inadequate smear' rates may be used to compare the quality of smears received in different laboratories, as there is a high level of agreement among cytologists as to what constitutes an inadequate smear. However, this is not true for "suboptimal smear" rates, and more precise reporting criteria must be defined and tested if an intermediate category is to be retained to report poor quality smears: more precise reporting criteria m...Continue Reading

References

Jan 1, 1990·Cytopathology : Official Journal of the British Society for Clinical Cytology

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Citations

Nov 9, 2002·Obstetrics and Gynecology·Anne-Marie E AmiesLaura Koutsky
Nov 10, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N SegnanS Ciatto
Aug 2, 2003·Journal of Clinical Pathology·Y L HockA Teale
Mar 14, 2000·Cytopathology : Official Journal of the British Society for Clinical Cytology·J HollingworthD Ireland
Feb 15, 2002·Cytopathology : Official Journal of the British Society for Clinical Cytology·G MiglioreM Branca
Aug 16, 2014·Cytopathology : Official Journal of the British Society for Clinical Cytology·M ConfortiniP Foxi
Aug 21, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·D MooreT Walker
Jun 21, 2005·Contraception·William F GriffithStephen F Heartwell

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