Interlaboratory validation of the in vitro eye irritation tests for cosmetic ingredients. (1) Overview of the validation study and Draize scores for the evaluation of the tests

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Y OhnoR Watanabe

Abstract

A three-step interlaboratory validation of alternative methods to the Draize eye irritation test (Draize test) was conducted by the co-operation of 27 organizations including national research institutes, universities, cosmetic industries, kit suppliers and others. Twelve alternative methods were evaluated using 38 cosmetic ingredients and isotonic sodium chloride solution. Draize tests were conducted according to the OECD guidelines using the same lot of test substances as was evaluated in the alternative tests. Results were as follows. (1) Variation in Draize scores was large near the critical range (maximal average Draize total scores (MAS)=15-50) for the evaluation of cosmetic ingredients. (2) Interlaboratory variation was relatively small for the alternative tests. The mean coefficients of variation (CV%) were less than 50 for all assays except for the hen's egg-chorioallantoic membrane test (HET-CAM), chorioallantoic membrane-trypan blue staining test (CAM-TB) and haemoglobin denaturation test (HD). The CV% of these three methods came into the same range as the other tests when non-irritants were excluded from the data analysis. (3) Results for acids (pH of 10% solution <2.5), alkalis (pH of 10% solution >11.5) and alcoho...Continue Reading

References

Feb 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N P Luepke
Jan 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S D GettingsJ Zyracki
Feb 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P G BrantomM Stern
Jun 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L K EarlM J Rowson
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S HaginoY Ohno
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Y OkamotoY Ohno
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M HataoY Ohno
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A KurishitaY Ohno
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T UchiyamaY Ohno
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·N TaniY Ohno
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K ChibaY Ohno
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H OkumuraY Ohno
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K MatsukawaY Ohno
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H ItagakiM Umeda
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S HaginoM Tanaka
Jul 1, 1992·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R GayA Ernesti
Jan 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S HaginoT Kobayashi

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Citations

Jul 26, 2006·Bulletin of Mathematical Biology·Maykel Cruz-MonteagudoYenny González-Díaz
Sep 4, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Masakazu KatohKen-ichiro Hata
Jun 8, 2002·Toxicology Letters·Manfred Liebsch, Horst Spielmann
Oct 18, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M P Vinardell, L García
Sep 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H Spielmann, M Liebsch
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T UchiyamaY Ohno
Apr 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P CourtellemontB Breda
Jul 23, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hiroyuki YamaguchiToshiaki Takezawa
May 3, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hajime Kojima
Sep 2, 2009·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Sanae MatsudaMasahiro Iwaki
Jul 16, 2014·Drug Development and Industrial Pharmacy·Anna Czajkowska-KośnikMałgorzata Sznitowska
Aug 19, 2007·Journal of Pharmaceutical Sciences·M P Vinardell, M Mitjans
Nov 1, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J ScognamiglioA M Api
Feb 5, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Hitoshi SakaguchiShinichi Watanabe
Jan 26, 2010·Journal of Pharmacological and Toxicological Methods·Frank A Barile
Feb 11, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Gina M YanochkoBart A Jessen
Nov 17, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·José CotovioJacques Leclaire
Jun 6, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Laurie ScottValérie Zuang
Jun 6, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sanae MatsudaMasahiro Iwaki
Oct 17, 2015·Journal of Applied Toxicology : JAT·Hiroyuki YamaguchiToshiaki Takezawa
Mar 27, 2013·Expert Opinion on Drug Metabolism & Toxicology·Sanjay L Dholakiya, Frank A Barile
Feb 6, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yutaka TakahashiNaohiro Nishiyama
Jun 30, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Kazuhiko HayashiNaohiro Nishiyama
Jun 12, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Hajime KojimaTakashi Morimoto
Feb 15, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Kazutoshi SaitoHitoshi Sakaguchi
Feb 17, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·James Z XingLi Xie
Feb 25, 2010·Cutaneous and Ocular Toxicology·Yutaka TakahashiNaohiro Nishiyama
Oct 5, 2006·Human & Experimental Toxicology·S Hoffmann, T Hartung
Aug 8, 2007·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Jodi S MathesonHoward Steinberg
Jul 31, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C Scully, J-V Bagan
Aug 30, 2014·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Kenichi Kasai
Dec 15, 2004·Alternatives to Laboratory Animals : ATLA·Lutz Edler, Carina Ittrich
May 29, 2010·Alternatives to Laboratory Animals : ATLA·Shigenobu HaginoHiroshi Itagaki

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