Interlaboratory validation of the in vitro eye irritation tests for cosmetic ingredients. (5) Skin(2TM) ZK1100 and tissue equivalent assay

Toxicology in Vitro : an International Journal Published in Association with BIBRA
A KurishitaY Ohno

Abstract

Skin(2TM) ZK1100 (ZK1100) assay and tissue equivalent assay (TEA, Skin(2TM) ZK1200) are human dermal models. These assays were evaluated as alternatives to the Draize eye irritation test (Draize test) in rabbits. Thirty-nine cosmetic ingredients were selected and used as test substances. The ZK1100 assay was conducted according to an original protocol provided by Advanced Tissue Sciences, a kit supplier. The TEA assay followed a protocol developed by Osborne et al., (1995a). Coefficients of variation (CV) ranged from 11.7 to 133 in results from the ZK1100 assay; three test substances showed the CVs more than 100. These were cetyltrimethylammonium chloride (S3-7), domiphen bromide (S3-11) and di(2-ethylhexyl) sodium sulfosuccinate (S3-14). Acid Red 92 (S2-3) was excluded from data analysis because its absorbance interfered with the endpoint of ZK1100 assay. The CVs from the TEA assay ranged from 31.8 to 119; two test substances showed the CVs more than 100. These were acetic acid and glycolic acid (S3-13). Butanol (S3-9) was excluded from the analysis because it was assumed to volatilize during a sample preparation. Pearson's coefficient of correlation with maximum average Draize total score (MAS) and 24hr score from the Draize ...Continue Reading

References

Apr 1, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P GautheronJ F Sina
Jul 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·L H BrunerR D Parker
Nov 1, 1986·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·F E FreebergL W Sanders
Feb 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A P Walker
Feb 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N P Luepke
Feb 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J LeightonR Tchao
Feb 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J B Price, I J Andrews
Aug 1, 1981·Food and Cosmetics Toxicology·A B BurtonR S Lawrence
Feb 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R Osborne, M A Perkins
Feb 1, 1994·The Journal of Toxicological Sciences·Y TaniguchiM Moriyasu
Jan 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M K Prinsen, H B Koëter
Nov 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R OsborneD A Roberts
Dec 1, 1982·International Journal of Cosmetic Science·M YorkG B Gibson
Feb 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P G BrantomM Stern
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A KurishitaY Ohno
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S J ReaderM Balls
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R Osborne, M A Perkins
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D TrigliaG K Naughton
Jul 1, 1992·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D M BagleyA P Walker
Jul 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H SpielmannW Steiling

❮ Previous
Next ❯

Citations

Jan 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R D CurrenJ F Régnier
Feb 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A KurishitaY Ohno
Dec 14, 2004·Journal of Colloid and Interface Science·A B Jódar-ReyesA Martín-Rodríguez
Jun 23, 2010·Expert Opinion on Drug Delivery·Gladys E Granero, Marcela R Longhi
Dec 15, 2004·Alternatives to Laboratory Animals : ATLA·Ludwig A Hothorn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Toxicology in Vitro : an International Journal Published in Association with BIBRA
K MatsukawaY Ohno
Toxicology in Vitro : an International Journal Published in Association with BIBRA
Y OkamotoY Ohno
Toxicology in Vitro : an International Journal Published in Association with BIBRA
M HataoY Ohno
Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
R OsborneD A Roberts
© 2021 Meta ULC. All rights reserved