Interleaved carbon minibeams: an experimental radiosurgery method with clinical potential

International Journal of Radiation Oncology, Biology, Physics
F Avraham DilmanianM Kerry O'Banion

Abstract

To evaluate the efficacy of "interleaved carbon minibeams" for ablating a 6.5-mm target in a rabbit brain with little damage to the surrounding brain. The method is based on the well-established tissue-sparing effect of arrays of thin planes of radiation. Broad carbon beams from the National Aeronautics and Space Agency Space Radiation Facility at Brookhaven National Laboratory were segmented into arrays of parallel, horizontal, 0.3-mm-thick planar beams (minibeams). The minibeams' gradual broadening in tissues resulted in 0.525-mm beam thickness at the target's proximal side in the spread-out Bragg peak. Interleaving was therefore implemented by choosing a 1.05 mm beam spacing on-center. The anesthetized rabbit, positioned vertically on a stage capable of rotating about a vertical axis, was exposed to arrays from four 90° angles, with the stage moving up by 0.525 mm in between. This produced a solid radiation field at the target while exposing the nontargeted tissues to single minibeam arrays. The target "physical" absorbed dose was 40.2 Gy. The rabbit behaved normally during the 6-month observation period. Contrast magnetic resonance imaging and hematoxylin and eosin histology at 6 months showed substantial focal target damag...Continue Reading

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Citations

Dec 10, 2015·Frontiers in Oncology·F Avraham DilmanianSunil Krishnan
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Frederik Vernimmen
Jan 13, 2015·Radiation Research·Andrew N FontanellaGregory M Palmer
Mar 17, 2015·International Journal of Radiation Oncology, Biology, Physics·F Avraham DilmanianSunil Krishnan
Feb 27, 2017·Medical Physics·Wilfredo GonzálezYolanda Prezado
May 31, 2017·Medical Physics·Immaculada Martínez-RoviraYolanda Prezado
Jan 11, 2018·Medical Physics·Toshiro TsubouchiAlbert Siegbahn
Apr 11, 2018·Medical Physics·W González, Y Prezado
Aug 23, 2017·Acta Oncologica·Thomas HenryAlbert Siegbahn
Sep 8, 2017·Medical Physics·Matthias SammerGünther Dollinger
Jun 8, 2019·Medical Physics·Tim SchneiderYolanda Prezado
Jul 11, 2020·Scientific Reports·John G EleySunil Krishnan
Oct 22, 2020·Cancers·Walter Tinganelli, Marco Durante
May 13, 2021·Radiation Research·Marco Durante

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