PMID: 6983710Jan 1, 1982Paper

Interleukin 1 activity in the synovial fluid of patients with rheumatoid arthritis

Rheumatology International
A FontanaG Cohen

Abstract

The synovial fluids (SF) of patients with rheumatoid arthritis (RA) were investigated for their effects on thymocytes of C3H/HeJ mice. Of the 20 SF tested, 17 (85%) showed an augmentation of the phytohaemagglutinin (PHA) induced thymocyte stimulation. Out of 16 SF of patients with osteoarthrosis, such an activity was detected in only one (6.25%). Further characterisation of the amplification factor revealed that (1) the SF of RA patients augmented both the PHA and the Concanavalin A response of the thymocytes (2) in the absence of mitogens, SF-treated thymocytes showed an increased uptake of 3H-thymidine, (3) the SF did not propagate the growth of an interleukin 2 dependent ovalbumin specific T cell clone, but (4) the SF were found to be required for optimal interleukin 2 release by spleen cells stimulated with suboptimal doses of lectin. Based on these biological effects the factor in the SF of RA patients is suggested to represent an interleukin 1 (IL-1). IL-1 produced in cultures by activated macrophages has been shown to stimulate T and B cell functions and to induce the production of collagenase and prostaglandins by cultured synovial cells. Both properties of IL-1 could be relevant in the pathogenesis of RA.

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Citations

Jan 1, 1986·Rheumatology International·K KatoS Kashiwazaki
Dec 4, 1998·Springer Seminars in Immunopathology·F M BrennanM Feldmann
Apr 1, 1993·Inflammation·D E HuT P Fan
Sep 1, 1985·Journal of Clinical Immunology·C A Dinarello
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May 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J NeidelJ Lindschau
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Jan 1, 1988·Springer Seminars in Immunopathology·K WaalenJ B Natvig
Jan 1, 1988·Springer Seminars in Immunopathology·M Steinitz
Apr 15, 1985·Experientia·T Kouri
Jun 1, 1990·Agents and Actions·J SchnyderT Payne
Jan 1, 1990·Rheumatology International·J B SmithJ L Abruzzo
Jan 1, 1990·Rheumatology International·K E HerbertD L Scott
Dec 13, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y T KonttinenC Friman
Aug 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·V LecomteM Raes
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Sep 11, 2002·Cytokine & Growth Factor Reviews·William P Arend

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