PMID: 8956986Jan 1, 1996Paper

Interleukin-1 alpha (IL-1 alpha) and N-formyl-methionyl-leucyl-phenylalanine (FMLP) as potential inducers of supravital chemotaxis

International Journal of Legal Medicine
W GrellnerS Dimmeler

Abstract

The phenomenon of artificially induced local leucocyte reactions during the supravital period could be of practical importance, but has not yet been comprehensively investigated. For a more detailed evaluation, experiments with the chemotactic agents interleukin-1 alpha (IL-1 alpha) and N-formyl-methionyl-leucyl-phenylalanine (FMLP) were performed by subcutaneous injection into various anatomical regions (back, abdomen, limbs) of NMRI-mice (National Medical Research Institute) and pigs 0-5 min after circulatory arrest. Phosphate buffered saline (PBS) without effective components was administered to equivalent areas of the animals as a control. Tissue specimens were collected at 6 h postmortem (mice) and 12-14 h postmortem (pigs), cut into serial sections, stained with H & E and examined under the microscope. A leucocyte reaction did not develop in pigs (n = 10, 30 tissue samples) following injection of FMLP, however, dermal, subcutaneous and perivascular infiltration of leucocytes (in particular mononuclear cells and a few granulocytes) was found in 3 out of 30 tissue specimens in murine experiments. In addition intravascular cell accumulations were detected in 2 out of 30 samples. The injection of IL-1 alpha to mice gave simil...Continue Reading

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E SchiffmannS M Wahl
Jan 1, 1990·Annual Review of Biochemistry·K I AraiT Yokota
Apr 1, 1988·Medicine, Science, and the Law·T T Ali
Feb 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L CordellD Y Mason
Aug 21, 1981·Science·R Snyderman, E J Goetzl
Oct 1, 1994·Current Opinion in Cell Biology·J Gailit, R A Clark
Dec 16, 1994·Forensic Science International : Synergy·B Madea
Dec 1, 1994·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·I OnoF Kaneko
Mar 29, 1993·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D A ParsellS Lindquist

❮ Previous
Next ❯

Citations

Jun 12, 2013·International Journal of Legal Medicine·Guillaume GauchotteLaurent Martrille
Dec 1, 2007·Forensic Science, Medicine, and Pathology·N E I Langlois
Jul 1, 2008·Journal of Forensic and Legal Medicine·J A Ortiz-ReyL Concheiro
Jun 30, 2006·Forensic Science International : Synergy·Wolfgang Grellner, Burkhard Madea
Jun 24, 2015·Medicine, Science, and the Law·Jean-Matthieu CasseGuillaume Gauchotte
Jan 26, 2017·Research in Veterinary Science·Kristiane Barington, Henrik Elvang Jensen
Jul 28, 2021·International Journal of Legal Medicine·Pierre-Antoine PeyronChristophe Hirtz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Forensic Science International : Synergy
Burkhard Madea
BMJ : British Medical Journal
S V Ramanan
International Journal of Legal Medicine
P BetzW Eisenmenger
© 2021 Meta ULC. All rights reserved