PMID: 8602595Mar 1, 1996Paper

Interleukin 1 and tumor necrosis factor in obese alcoholics compared with normal-weight patients

The American Journal of Clinical Nutrition
D BunoutM Pettermann

Abstract

We performed a liver biopsy and measured plasma concentrations of interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha), and spontaneous and lipopolysaccharide-stimulated in vitro monocyte production of IL-1 beta and TNF-alpha in 19 obese and 17 age-matched, normal-weight alcoholics admitted for treatment of their alcoholism. Nine healthy normal-weight alcoholics had cirrhosis in their liver biopsy (Fisher's exact test: P=0.031). A histologic score (derived from the sum of fat, necrosis, fibrosis, and inflammation in the biopsy) correlated with body mass index and the percentage body fat, calculated by using the sum of four skinfold-thickness measures. Plasma concentrations and spontaneous in vitro monocyte production of IL-1 beta and TNF-alpha were below detection limits. No significant differences were observed between normal-weight and obese alcoholics with or without cirrhosis and normal control subjects in lipopolysaccharide-stimulated monocyte production of IL-1 beta (6.5 +/- 0.8, 10.1 +/- 2.7, 7.9 +/- 1.6, and 5.28 +/- 4.24 micrograms/L, respectively) or TNF-alpha (2.8 +/- 0.4, 3.7 +/- 1.0, 3.0 +/- 0.44, and 1.97 +/- 1.01 micrograms/L, respectively). However, a positive correlation was found between ...Continue Reading

Citations

May 12, 2012·Arthritis and Rheumatism·Craig R LouerFarshid Guilak
Nov 28, 2013·Annual Review of Physiology·Jorge Henao-MejiaRichard A Flavell
Jul 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Thomas GalboGerald I Shulman
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·M P de la MazaD Bunout
Dec 7, 2011·Experimental Diabetes Research·B L GuilfordD E Wright
Apr 20, 2002·European Journal of Clinical Nutrition·N MitoK Sato
Jun 8, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·M Berberoğlu
May 24, 2005·Nature Immunology·Scott T Weiss
Feb 19, 2010·Molecular Nutrition & Food Research·Seung-Jin KimTaesun Park
Nov 18, 2015·Immunology·Martha TriantafilouKathy Triantafilou
Jun 18, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elizabeth E PowellAndrew D Clouston
Aug 25, 1999·Metabolism: Clinical and Experimental·M K Bhattacharya, M A Khaled
Mar 6, 2012·Cell·Varman T Samuel, Gerald I Shulman
Mar 19, 2011·The Journal of Nutritional Biochemistry·Seung-Jin KimTaesun Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.