PMID: 10417196Jul 23, 1999Paper

Interleukin-1 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide

Infection and Immunity
C Y ChiangSalomon Amar


The present study was undertaken to test the hypothesis that tumor necrosis factor (TNF) and/or interleukin-1 (IL-1) activity mediates lipopolysaccharide (LPS)-induced bone resorption in vivo. To test this hypothesis, Escherichia coli LPS or Porphyromonas gingivalis LPS was injected into the subcutaneous tissues overlying mouse calvariae. Histological sections, prepared from the center of the lesion, were stained for tartrate-resistant acid phosphatase, and histomorphometric analysis was performed to quantify the osteoclast number and the area of bone resorption. In time course experiments using normal mice, a peak of bone resorption occurred 5 days after endotoxin stimulation. In dose-response experiments, IL-1 receptor type 1 deletion (IL-1R(-/-)), TNF double-receptor p55/p75 deletion (TNF p55(-/-)/p75(-/-)), combined TNF p55 and IL-1 receptor type 1 deletion (TNF p55(-/-)/IL-1R(-/-)), and IL-1beta-converting enzyme-deficient (ICE(-/-)) mice and the respective wild-type mice were injected with 500, 100, or 20 micrograms of P. gingivalis LPS and sacrificed 5 days after LPS injection. At the highest dose (500 micrograms), significant decreases in osteoclast number occurred in mutant mice compared to wild-type mice: (i) a 64% re...Continue Reading


Feb 1, 1992·Endocrine Reviews·T SudaT J Martin
Feb 8, 1990·The New England Journal of Medicine·R C Williams
Nov 1, 1989·Journal of Periodontal Research·A UmezuH Itoh
Feb 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J PfeilschifterG D Roodman
Sep 1, 1989·Endocrinology·B F BoyceG R Mundy
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M SabatiniG R Mundy
Jun 1, 1986·The Journal of Clinical Investigation·C A DinarelloR C Reuben
Jan 1, 1987·Annual Review of Medicine·D C Morrison, J L Ryan
May 1, 1972·Journal of Periodontology·J SchwartzR B Parker
Dec 1, 1973·Archives of Oral Biology·E Hausmann, N Weinfeld
Feb 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H L UyG D Roodman
Apr 1, 1994·The Journal of Clinical Investigation·G GirasoleS C Manolagas
Nov 1, 1993·Journal of Periodontal Research·H Birkedal-Hansen
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J E SimsK Shanebeck
Apr 1, 1993·Immunobiology·C Galanos, M A Freudenberg
Oct 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M KoideK Hara
Sep 18, 1997·The Journal of Clinical Investigation·Y Abu-AmerS L Teitelbaum
Nov 14, 1997·The Journal of Experimental Medicine·J RubyJ J Peschon

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