Interleukin 1 and tumor necrosis factor potentiate angiotensin II- and calcium ionophore-stimulated prostaglandin E2 synthesis in rat renal mesangial cells

Biochemical and Biophysical Research Communications
J Pfeilschifter, H Mühl

Abstract

In resting mesangial cells, angiotensin II and the calcium ionophore A23187 stimulated prostaglandin E2 (PGE2) formation. After pretreatment with interleukin 1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF alpha), which are themselves potent stimuli for PGE2 synthesis, mesangial cells displayed an amplified response to angiotensin II and A23187. The cytokine-induced effects occurred in a time- and dose-dependent manner and were attenuated by actinomycin D, cycloheximide and dexamethasone. IL-1 beta and TNF alpha treatment also increased the amount of arachidonic acid released after stimulation of cells with angiotensin II and A23187. In addition, IL-1 beta but not TNF alpha treatment augmented the formation of PGE2 from exogenous arachidonic acid by mesangial cells. Furthermore, the conversion of prostaglandin H2 to PGE2 was not changed by IL-1 beta and TNF alpha. These results suggest that IL-1 beta and TNF alpha exert a priming effect on PGE2 production in mesangial cells.

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Citations

Jan 1, 1993·European Journal of Clinical Pharmacology·J PfeilschifterH van den Bosch
May 4, 2011·Nature Reviews. Nephrology·Juan F Navarro-GonzálezJavier García-Pérez
Sep 3, 2011·Critical Care : the Official Journal of the Critical Care Forum·Jan Willem KuiperA B Johan Groeneveld
Mar 3, 2009·Cytokine & Growth Factor Reviews·Juan F Navarro-GonzálezJavier García
Mar 19, 2015·Journal of Diabetes Research·Javier Donate-CorreaJuan F Navarro-González
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Juan F Navarro-González, Carmen Mora-Fernández
Nov 17, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eva Feigerlová, Shyue-Fang Battaglia-Hsu
Jan 11, 2013·Physiological Reviews·Josephine M Forbes, Mark E Cooper
Feb 9, 2021·Frontiers in Medicine·Javier Donate-CorreaJuan F Navarro-González
Feb 12, 1998·The American Journal of Physiology·N R FerreriJ C McGiff

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