Interleukin-1β as emerging therapeutic target in hematological malignancies and potentially in their complications

Blood Reviews
Lorena ArranzAlicia Villatoro

Abstract

Interleukin-1β (IL-1β) is a pleiotropic cytokine that exerts multiple roles in both physiological and pathological conditions. It is produced by different cell subsets, and drives a wide range of inflammatory responses in numerous target cells. Enhanced IL-1β signaling is a common event in patients of hematological malignancies. Recent body of evidence obtained in preclinical models shows the pathogenic role of these alterations, and the promising therapeutic value of IL-1 targeting. In this review, we further highlight a potential contribution of IL-1β linking to complications and autoimmune disease that should be investigated in future studies. Hence, drugs that target IL-1 may be helpful to improve outcome or reduce morbidity in patients. Some of them are FDA-approved, and used efficiently against autoimmune diseases, like IL-1 receptor antagonist. In the clinic, however, this agent seems to have limited properties. Current improved drugs will allow to determine the true potential of IL-1 and IL-1β targeting as therapy in hematological malignancies and their related complications.

Citations

Nov 29, 2017·Frontiers in Oncology·Shayda HemmatiKira Gritsman
Aug 31, 2018·International Journal of Molecular Sciences·Joanna Konieczny, Lorena Arranz
Aug 10, 2019·International Journal of Molecular Sciences·Anne Sophie Kubasch, Uwe Platzbecker
Nov 30, 2019·International Journal of Molecular Sciences·Muamera SarajlicJutta Horejs-Hoeck
Jan 5, 2020·International Journal of Oral Science·Ran ChengTao Hu
May 24, 2020·Journal of Clinical Medicine·Alice PievaniMarta Serafini
Dec 11, 2020·The British Journal of Nutrition·Qianqian XuXinyang Dong
Feb 3, 2021·International Journal of Molecular Sciences·Laura UrwanischJutta Horejs-Hoeck
Dec 3, 2021·Leukemia & Lymphoma·Julian A WaksalJohn O Mascarenhas

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