PMID: 8971655Nov 1, 1996Paper

Interleukin-1 beta and phenytoin reduce alpha 1 (I) procollagen mRNA expression in human gingival fibroblasts

Journal of Periodontal Research
T ModéerG Andersson

Abstract

Effects of and interactions between interleukin-1 beta (IL-1 beta) and phenytoin (PHT) on alpha 1 (I) procollagen gene and protein expression in human gingival fibroblasts and its relation to prostaglandin E2 (PGE2) formation were studied. IL-1 beta (300 pg/ ml) reduced the steady-state level of alpha 1 (I) procollagen mRNA by 50% and decreased the amount of procollagen I by 35%. PHT (10 micrograms/ml) reduced the level of alpha 1 (I) procollagen mRNA by 40% but the amount of procollagen I in the medium was unchanged. In combination with IL-1 beta, PHT potentiated the inhibitory effect of IL-1 beta on alpha 1 (I) procollagen mRNA level that was accompanied by an increased PGE2 formation. Preincubation with indomethacin (10(-6) M) partially reduced the inhibitory effect of IL-1 beta as well as of IL-1 beta in combination with PHT on the mRNA level of alpha 1 (I) procollagen. The inhibitory effect of PHT was unaffected by indomethacin treatment. Addition of exogenous PGE2 (> or = 10 nM) dose-dependently reduced steady-state level of alpha 1 (I) procollagen mRNA as well as the amount of procollagen 1. The study indicates that IL-1 reduces the expression of alpha 1 (I) procollagen mRNA in human gingival fibroblasts partly by a pros...Continue Reading

References

Jul 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T ModéerU H Lerner
Jul 1, 1990·Journal of Periodontal Research·D Richards, R B Rutherford
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Jan 11, 1988·Nucleic Acids Research·J K MäkeläE Vuorio
Jun 1, 1986·Community Dentistry and Oral Epidemiology·T ModéerK Theorell
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Dec 1, 1972·Oral Surgery, Oral Medicine, and Oral Pathology·A P Angelopoulos, P W Goaz
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S B MizelS E Mergenhagen
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Aug 1, 1980·Biochimica Et Biophysica Acta·J Goultschin, S Shoshan

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Citations

May 22, 2013·Mediators of Inflammation·Tamilselvan SubramaniNoorjahan Banu Alitheen
Oct 13, 2011·ISRN Dentistry·Jôice Dias CorrêaTarcilia Aparecida Silva
Jun 10, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P C Trackman, A Kantarci
Jan 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·B Wondimu, T Modéer
Jul 29, 1998·Oral Diseases·R I Marshall, P M Bartold

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