PMID: 9164638Apr 1, 1997Paper

Interleukin 1 beta and the stimulation of Langerhans cell migration: comparisons with tumour necrosis factor alpha

Archives of Dermatological Research
M CumberbatchI Kimber

Abstract

Epidermal Langerhans cells (LC) and the cells into which they mature are believed to play a pivotal role in cutaneous immune function. The induction phase of contact sensitization is associated with the migration of LC from the skin and their accumulation as dendritic cells (DC) in lymph nodes draining the site of exposure. We have demonstrated previously that tumour necrosis factor alpha (TNF-alpha), an epidermal cytokine produced by keratinocytes, provides one signal for LC migration. We describe here experiments designed to evaluate the influence of interleukin 1 beta (IL-1 beta), a product exclusively of LC in murine epidermis, on LC migration, LC morphology and DC accumulation, and to compare the effects of this cytokine with those of TNF-alpha. Both cytokines induced a significant reduction in the frequency of epidermal LC and the arrival of DC in draining lymph nodes. Changes in both parameters were induced more rapidly following intradermal administration of TNF-alpha than were observed after treatment with IL-1 beta. However, the reduction in LC frequency was more persistent with IL-1 beta. Both cytokines caused the activation of LC, characterized by the acquisition of a more dendritic morphology and the increased expr...Continue Reading

Citations

Jul 1, 1997·Clinical Reviews in Allergy & Immunology·I Kimber, R J Dearman
Mar 12, 2002·Archives of Pharmacal Research·Seongwon Choi
Jul 14, 1999·Toxicology Letters·I KimberR J Dearman
Jul 25, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J S PichowskiI Kimber
Oct 18, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H TuschlE Weber
Sep 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H Tuschl, R Kovac
May 22, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·W D Pennie, I Kimber
Jan 16, 1999·Free Radical Biology & Medicine·K RutaultD R Katz
Jan 23, 1999·Current Opinion in Immunology·I KimberR J Huby
Jan 12, 2001·Journal of Photochemistry and Photobiology. B, Biology·M S DuthieM Norval
Sep 1, 1999·The British Journal of Dermatology·M CumberbatchI Kimber
Mar 29, 2000·The British Journal of Dermatology·I KimberC E Griffiths
Nov 13, 2001·The British Journal of Dermatology·S W ChoiM H Chung
May 16, 2000·Immunology·M CumberbatchI Kimber
Jun 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A J MonteroJ J Kavanagh
Oct 18, 2001·Journal of the American College of Nutrition·O M Conneely
Oct 27, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E BuentkeA Scheynius
Jul 27, 2006·Expert Opinion on Drug Metabolism & Toxicology·Farah D KhanCraig K Svensson
Dec 31, 1997·The Journal of Experimental Medicine·A A PriceA Ager
Nov 25, 2006·Journal of Dermatological Science·Akiko NishibuAkira Takashima
Jul 7, 2005·Photodermatology, Photoimmunology & Photomedicine·Beata SkibaTerrence J Piva
Apr 18, 2003·Clinical and Experimental Immunology·M CumberbatchC E M Griffiths
Sep 21, 2001·The Journal of Investigative Dermatology·T KoppT S Kupper
Jul 13, 2004·The Journal of Investigative Dermatology·Dagmar von BubnoffHenri de la Salle
Sep 13, 2005·Cytokine·C E M GriffithsI Kimber
Jan 24, 2003·Expert Opinion on Therapeutic Targets·Philip A Reay
Jun 4, 2014·Dermatologic Clinics·Alexandra Gruber-WackernagelPeter Wolf
Jun 27, 2012·Biochemical and Biophysical Research Communications·Nobutake YamamichiKazuhiko Koike
Jul 1, 2007·Expert Review of Clinical Immunology·Simon Fillatreau, Stephen M Anderton
Jul 22, 2017·Biotechnology Advances·Dongyun LeiLi He
Apr 16, 2018·The FEBS Journal·Natalia Muñoz-Wolf, Ed C Lavelle
Mar 23, 2001·Nature Immunology·M Moser, K M Murphy
Sep 18, 2004·Mass Spectrometry Reviews·Chun-Ming HuangDe-Chu C Tang
Dec 20, 2018·Experimental Dermatology·Carine MainzerYoshikazu Uchida
Jul 15, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cindy A RyanIan Kimber
Jul 31, 1999·European Journal of Immunology·P KelleherS C Knight

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