PMID: 8941762Apr 1, 1996Paper

Interleukin-1 beta and tumor necrosis factor-alpha stimulate synergistically the expression of monocyte chemoattractant protein-1 in fibroblastic cells derived from human periodontal ligament

Oral Microbiology and Immunology
K OzakiS Kitano

Abstract

The present study demonstrates that interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) induce and synergistically stimulate monocyte chemoattractant protein-1 (MCP-1) expression in fibroblasts from human periodontal ligament. IL-1 beta and TNF-alpha induced in a dose-dependent manner the expression of the MCP-1 gene in the fibroblasts from the human periodontal ligament. However, such an inducing effect was not observed with IL-6 and interferon-gamma. The peak expression of the MCP-1 gene by IL-1 beta or TNF-alpha was observed at 3 h after initiation of their treatment. Furthermore, IL-1 beta in combination with TNF-alpha synergistically stimulated the MCP-1 gene expression in the cells. We also observed significant chemotactic activity for human monocytes in conditioned medium of fibroblasts from the human periodontal ligament treated with both cytokines. The stimulated chemotactic activity induced by these cytokines depended on both dose and treatment time. The chemotactic activity in conditioned medium of IL-1 beta-treated fibroblasts from the human periodontal ligament was neutralized by antiserum specific for MCP-1 protein. The MCP-1 gene product in conditioned medium of IL-1 beta-treated fibroblast...Continue Reading

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Citations

Jan 25, 2005·Infection and Immunity·Manoj MuthukuruChristopher W Cutler
Jan 27, 2004·American Journal of Respiratory Cell and Molecular Biology·Elena TourkinaStanley Hoffman
Nov 18, 2005·Biochemical and Biophysical Research Communications·Helena DomeijTülay Yucel-Lindberg
Oct 5, 2007·Burns : Journal of the International Society for Burn Injuries·Yasuhiro TsudaFujio Suzuki
Jun 26, 2007·Journal of Dental Research·A MaedaT Matsuguchi
May 5, 2018·Journal of Cell Science·Yongqiang WangChristopher A McCulloch
Aug 13, 2002·Oncogene·Steven A JohnsenThomas C Spelsberg
Oct 13, 2005·The New Phytologist·Frédéric DanjonDidier Bert
May 18, 2006·American Journal of Physiology. Renal Physiology·Kunihiro HayakawaMasanori Kitamura
Jun 28, 2011·International Journal of Clinical Oncology·Takayuki MuraokaShinichiro Miyoshi
Nov 14, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mitsufumi NakawakiMasashi Takaso
Jan 23, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ayumu KawakuboMasashi Takaso
Dec 2, 2010·Journal of Periodontal Research·D JönssonB-O Nilsson
Jun 17, 2020·Immunopharmacology and Immunotoxicology·Ikuko HosokawaTakashi Matsuo
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·N SolerR Rodriguez-Roisin
Mar 23, 2017·Frontiers in Immunology·Samantha E Heron, Shokrollah Elahi
Mar 6, 1998·Infection and Immunity·S AgarwalC Baran
Oct 17, 2019·Ocular Immunology and Inflammation·Li-Fong SeetTina T Wong
Mar 24, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jing YangTakashi Ikejima

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