PMID: 9536948Apr 16, 1998Paper

Interleukin 1 beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways

Gut
I Beales, J Calam

Abstract

The cytokines interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) are inhibitors of gastric acid secretion when administered systemically. To investigate the inhibitory effect of IL-1 beta and TNF-alpha on cultured, acid secreting parietal cells in order to determine the mechanism of this inhibition. Rabbit parietal cells were prepared by collagenase-EDTA digestion and counter flow elutriation. Acid secretory activity was assessed by aminopyrine accumulation. IL-1 beta and TNF-alpha inhibited basal and stimulated acid secretion in a dose dependent manner; near maximal effects were seen with both at 10 ng/ml. Inhibition was maximal with 15 minutes pretreatment but seen with up to 18 hours of preincubation. Both cytokines inhibited histamine, carbachol, gastrin, forskolin, and A23187 stimulated acid secretion but had no effect on stimulation by dibutyryl-cAMP. Inhibition of acid secretion was not accompanied by a change in radioligand binding to histamine H2 or gastrin/CCKB receptors. Pertussis toxin abolished the inhibitory effects on histamine and forskolin stimulation. The tyrosine kinase inhibitor herbimycin reduced the inhibitory effects of TNF-alpha against all stimuli but only reduced the effects of...Continue Reading

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Citations

Feb 17, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Mitsushige Sugimoto, Yoshio Yamaoka
Sep 3, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Andrzej HnatyszynRyszard Slomski
Jul 10, 2007·Cancer Immunology, Immunotherapy : CII·Jovanny ZabaletaAugusto C Ochoa
Oct 23, 2009·Current Microbiology·Tania Beatriz Romero-AdriánAna Antúnez
Oct 8, 2005·Journal of Gastroenterology·Atsushi MuramatsuMasaru Kuriyama
Feb 28, 2006·Journal of Gastroenterology·Tsutomu ChibaKazuichi Okazaki
May 9, 2012·Journal of Gastroenterology·Adam J Smolka, Steffen Backert
Dec 28, 2007·Glycoconjugate Journal·Feng-Ling YangShih-Hsiung Wu
Sep 12, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Carlo-Federico ZambonSergio Pedrazzoli
Sep 28, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ming LiYahong Gu
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Jun 8, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Kuniharu IshikiYasushi Shiratori
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