Interleukin-1 Beta as a Target for Atherosclerosis Therapy: Biological Basis of CANTOS and Beyond

Journal of the American College of Cardiology
Peter Libby

Abstract

Inflammatory pathways drive atherogenesis and link conventional risk factors to atherosclerosis and its complications. One inflammatory mediator has come to the fore as a therapeutic target in cardiovascular disease. The experimental and clinical evidence reviewed here support interleukin-1 beta (IL-1β) as both a local vascular and systemic contributor in this regard. Intrinsic vascular wall cells and lesional leukocytes alike can produce this cytokine. Local stimuli in the plaque favor the generation of active IL-1β through the action of a molecular assembly known as the inflammasome. Clinically applicable interventions that interfere with IL-1 action can improve cardiovascular outcomes, ushering in a new era of anti-inflammatory therapies for atherosclerosis. The translational path described here illustrates how advances in basic vascular biology may transform therapy. Biomarker-directed application of anti-inflammatory interventions promises to help us achieve a more precise and personalized allocation of therapy for our cardiovascular patients.

References

Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J V CastellP C Heinrich
Dec 1, 1986·The Journal of Clinical Investigation·P LibbyC A Dinarello
May 1, 1987·The Journal of Experimental Medicine·S J WarnerP Libby
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P E AuronC A Dinarello
May 1, 1981·The Journal of Experimental Medicine·C A Dinarello
Mar 17, 1999·The Journal of Clinical Investigation·J GoslingI F Charo
Nov 5, 1999·Nature Medicine·E LutgensR A Flavell
Jan 19, 2000·The Journal of Experimental Medicine·M J NicklinG W Duff
Jun 17, 2000·The International Journal of Biochemistry & Cell Biology·U SchönbeckP Libby
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·E LutgensM J Daemen
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Hirokazu KiriiMitsuru Seishima
Apr 3, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Kikuo IsodaFumitaka Ohsuzu
Jan 7, 2005·The New England Journal of Medicine·Paul M RidkerUNKNOWN Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) Inv
Oct 4, 2005·Journal of the American College of Cardiology·Peter Libby
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Dec 23, 2006·Nature Reviews. Immunology·Sanjeev Mariathasan, Denise M Monack
May 21, 2008·Circulation·William F Fearon, Douglas T Fearon
Nov 5, 2008·The Journal of Clinical Investigation·Marc Feldmann
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Mar 24, 2009·Annual Review of Immunology·Charles A Dinarello
Jun 6, 2009·The New England Journal of Medicine·Helen J LachmannUNKNOWN Canakinumab in CAPS Study Group
Nov 28, 2009·Journal of the American College of Cardiology·Peter LibbyUNKNOWN Leducq Transatlantic Network on Atherothrombosis
Apr 28, 2010·Cancer Metastasis Reviews·Charles A Dinarello
Jul 16, 2010·Blood·Loems Ziegler-HeitbrockManfred B Lutz
Mar 25, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·G Thomas Brown, Thomas M McIntyre
Apr 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Hafid Ait-OufellaAlain Tedgui

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Citations

Mar 21, 2018·The Annals of Pharmacotherapy·Brandon K Martinez, C Michael White
Mar 20, 2018·Current Opinion in Lipidology·Laurent Yvan-Charvet, Bertrand Cariou
May 16, 2018·European Journal of Preventive Cardiology·Viviane Z Rocha, Raul D Santos
Aug 2, 2018·Nature Reviews. Cardiology·Luigi Ferrucci, Elisa Fabbri
Mar 14, 2018·Circulation·Erin A BohulaMarc S Sabatine
Nov 13, 2018·Journal of Cellular Physiology·Aldo Bonaventura, Fabrizio Montecucco
Jan 17, 2019·JAMA Cardiology·Thomas S G SehestedJeremy D Goldhaber-Fiebert
Jan 18, 2019·Circulation Research·Dennis Wolf, Klaus Ley
Feb 7, 2019·Archives of Pharmacal Research·Jong-Gil Park, Goo Taeg Oh
Mar 1, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter Libby, Brendan M Everett
May 17, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·John E Mindur, Filip K Swirski
Mar 26, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Camilla UdjusKarl-Otto Larsen
May 24, 2019·European Heart Journal·Esther LutgensChristian Weber
Jun 12, 2019·Journal of the American Heart Association·Ying Jin, Jian Fu
Jun 9, 2019·Seminars in Immunopathology·Marina MesquidaSascha Fauser
May 3, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rosan A Van ZoestFerdinand W Wit
Jul 12, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Hafid Ait-OufellaAlain Tedgui
Jun 30, 2019·British Journal of Pharmacology·Jennifer L Harman, Helle F Jørgensen
Oct 28, 2019·Journal of Clinical Medicine·Luca LiberaleFabrizio Montecucco
Sep 1, 2019·Current Pharmaceutical Design·Luca Liberale, Giovanni G Camici
Jan 31, 2019·European Heart Journal·Amélie VrommanPeter Libby
Jan 22, 2020·Journal of the American Heart Association·Joseph Pierre AboumsallemRudolf A de Boer
Feb 2, 2020·European Heart Journal·Luca LiberaleGiovanni G Camici
Mar 17, 2020·European Heart Journal·Patrick R LawlerPaul M Ridker
Mar 17, 2020·Future Medicinal Chemistry·Yee-Hung Chan, Dipak P Ramji
Jan 11, 2020·Internal and Emergency Medicine·Federico BiscettiRaffaele Landolfi
Apr 24, 2020·Circulation Research·Peter Libby, Karin E Bornfeldt
Jun 6, 2020·Scandinavian Cardiovascular Journal : SCJ·Anders HovlandKnut Tore Lappegård
Jun 5, 2020·Toxins·Maribel Diaz-RicartGines Escolar
Jul 18, 2020·Asian Cardiovascular & Thoracic Annals·Lara Jane RimmerMohamad Bashir

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