PMID: 8964907May 1, 1996Paper

Interleukin-1 beta differentially affects interleukin-6 and soluble interleukin-6 receptor in the blood and central nervous system of the monkey

Journal of Neuroimmunology
T M Reyes, Christopher L Coe

Abstract

Two studies were conducted to investigate whether behavioral and physiological responses induced by administration of interleukin-1 beta (IL-1 beta) were also associated with changes in interleukin-6 (IL-6) and soluble IL-6 receptor levels (sIL-6R). Following intravenous injection of rhIL-1 beta, blood and cerebrospinal fluid (CSF) samples were collected from juvenile rhesus monkeys. Marked increases in IL-6 levels were evident at 1 h in both blood and intrathecal compartments. IL-1 beta also induced significant elevations in the release of ACTH and cortisol into the blood stream, and following high doses, the monkeys evinced signs of sickness behavior. The second study characterized the IL-beta dose-response relationship showing that these physiological changes were most evident at doses between 0.5 microgram and 1.0 microgram IL-1/kg body weight. Soluble IL-6 receptor concentration was also increased, but only in plasma. There was no detectable sIL-6R in CSF. The large release of IL-6 into CSF suggests that some behavioral symptoms may be due to intrinsic changes in central nervous system activity concomitant with the alterations in peripheral physiology.

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Citations

Oct 24, 1998·Domestic Animal Endocrinology·R W Johnson
Sep 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rozita ShiraziKarolina Patrycja Skibicka
Sep 25, 2012·Frontiers in Neuroendocrinology·Jennifer C Felger, Andrew H Miller
Feb 28, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Yanan ZhuMitchell K P Lai
Jul 28, 2011·Expert Review of Clinical Immunology·J Pablo Abonia, Philip E Putnam
Dec 24, 2018·Aging and Disease·Antonina LucaMaria Luca
Jan 7, 2005·Anatomical Science International·Makoto Ishibashi
Jun 14, 2018·Molecular Psychiatry·Jennifer C FelgerAndrew H Miller
Feb 12, 1998·The American Journal of Physiology·T M Reyes, C L Coe
Jun 24, 2008·CNS Spectrums·Leah McNallyJonas Hannestad
Aug 4, 1998·The American Journal of Physiology·T M Reyes, C L Coe
Aug 12, 2009·Neuroscience and Biobehavioral Reviews·Nicole DellaGioia, Jonas Hannestad

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