PMID: 11898392Mar 20, 2002Paper

Interleukin-1 beta exerts a myriad of effects in the brain and in particular in the hippocampus: analysis of some of these actions

Vitamins and Hormones
Marina A Lynch

Abstract

The realization, in the past decade or so, that bidirectional communication between the central nervous system and the immune system was likely has sparked an explosion of interest in the roles certain cytokines, particularly the proinflammatory cytokine interleukin-1 beta (IL-1 beta), might play in the brain. The observation that IL-1 type I receptor was expressed in highest density in the hypothalamus was of significance in identifying a role for IL-1 beta in neuroendocrine modulation. However, the finding that receptor expression was also high in the hippocampus, an area of the brain which plays a pivotal role in memory and learning, has led to uncovering a role for IL-1 beta in cognitive function. There is now a great deal of evidence suggesting that IL-1 beta plays a significant role in hippocampal synaptic function, and the possibility that IL-1 beta may trigger some of the detrimental changes in certain neurodegenerative diseases is currently being assessed. The review addresses some of the issues relating to the role of IL-1 beta in the brain, specifically in the hippocampus.

Citations

Dec 10, 2015·Neural Plasticity·Venkata Subba Rao AtluriMadhavan Nair
Jan 13, 2004·Physiological Reviews·M A Lynch
May 31, 2018·Hypertension·Erin CiampaPhilip E Hess
Mar 26, 2002·The Journal of Biological Chemistry·Peter E LonerganMarina A Lynch
Mar 24, 2005·Neuroimmunomodulation·Yvonne NolanMarina A Lynch
Dec 6, 2003·The European Journal of Neuroscience·Velia D'Agata, Sebastiano Cavallaro
Jun 12, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Nicolas P TurrinMichael M Meguid
Jun 28, 2007·Reviews in the Neurosciences·Carmelina Gemma, Paula C Bickford
Nov 16, 2007·The European Journal of Neuroscience·Carmelina GemmaPaula C Bickford
Aug 17, 2012·Neurotoxicity Research·Laura L Hurley, Yousef Tizabi
Nov 7, 2013·Nutritional Neuroscience·Linnea R FreemanAnn-Charlotte Granholm
Oct 4, 2005·The European Journal of Neuroscience·Carmelina GemmaPaula C Bickford
Nov 8, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ofra Ben Menachem-ZidonRaz Yirmiya
Oct 23, 2020·The International Journal of Neuroscience·Sachin P BorikarKishor R Danao
Oct 2, 2020·Brain, Behavior, and Immunity·Patricia SchroederSeija Lehnardt

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